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Overlapping of Organic Disorders with Irritable Bowel Syndrome Among Teachers in Tabuk, Saudi Arabia Using Rome III Criteria
Abdulateef Elbadawi,
Hyder Mirghani,
Talal Khalid Alanazi,
Abdulaziz Hamoud Alanazi,
Meshal Faleh Alenezi
Issue:
Volume 5, Issue 1, January 2017
Pages:
1-4
Received:
28 November 2016
Accepted:
9 December 2016
Published:
13 January 2017
Abstract: Irritable bowel syndrome (IBS) is the most commonly diagnosed gastrointestinal disorder leading to losing of work days, only 15% of patients seek medical advice. In this study, we aimed to investigate IBS among teachers in Tabuk. A cross-sectional study conducted among 362 teachers in Tabuk City during the period from January 2015 to June 2015, they were selected randomly from a total number of 25 schools, participants were invited to sign a written informed consent, then responded to a structured questionnaire based on socio-demographic data, and the Rome III criteria. The research was approved by the ethical committee of the University of Tabuk. The Statistical Package for Social Sciences was used for data analysis; the chi-square was used to compare categorical data. The result shows that IBS was evident in 14.1% of teachers, IBS patients were more likely to have travelling history, and flag signs (fever, bleeding per rectum, and loss of weight) P-value<0.05., no differences were found between teachers with IBS and those without the disease regarding age, sex, marital status, and family history of the disease P-value >0.05. In conclusion: irritable bowel syndrome is prevalent among teachers in Tabuk, Saudi Arabia, flag signs and history of travel are commoner among those who fulfill the Rome III criteria. Physicians may need more tests to rule out organic disorders; large multicenter studies are required to rule the associations of IBS with microscopic colitis and carcinoma of the colon.
Abstract: Irritable bowel syndrome (IBS) is the most commonly diagnosed gastrointestinal disorder leading to losing of work days, only 15% of patients seek medical advice. In this study, we aimed to investigate IBS among teachers in Tabuk. A cross-sectional study conducted among 362 teachers in Tabuk City during the period from January 2015 to June 2015, the...
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Identification of Methicillin-Resistant Staphylococcus Epidermidis (MRSE) in Mild, Moderate and Severe Acne Patients
Farida Tabri,
Nasrum Massi,
Risalinda Sjahrir,
Ilhamjaya Patellongi,
Siswanto Wahab,
Khairuddin Djawad
Issue:
Volume 5, Issue 1, January 2017
Pages:
5-9
Received:
9 December 2016
Accepted:
21 December 2016
Published:
16 January 2017
Abstract: Acne cases caused by Staphylococcus epidermidis bacteria have been reported previously. This study identified methicillin resistant Staphylococcus epidermidis (MRSE) directly from pus speciment from acne patients at various degree of severity. There were 61% positive samples detected by Polymerase Chain Reaction (PCR) for MRSE using target gene mecA for PCR amplification of acne samples. Significant correlation between the severity of acne and its causative agent (MRSE) was not found.
Abstract: Acne cases caused by Staphylococcus epidermidis bacteria have been reported previously. This study identified methicillin resistant Staphylococcus epidermidis (MRSE) directly from pus speciment from acne patients at various degree of severity. There were 61% positive samples detected by Polymerase Chain Reaction (PCR) for MRSE using target gene mec...
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Profile of mRNA Expression of Ki-67 in Breast Cancer Patients Pre- and Post- Chemotherapy
Prihantono Prihantono,
Daniel Sampepajung,
Andi Asadul Islam,
Mochammad Hatta,
Warsinggih Rahardjo,
Christian Binekada,
Eddy Herman Tanggo
Issue:
Volume 5, Issue 1, January 2017
Pages:
10-14
Received:
7 December 2016
Accepted:
20 December 2016
Published:
19 January 2017
Abstract: Background: Proliferation is a distinct hallmarks of cancer. Ki-67 designated as a marker of proliferation in solid tumors. The proliferative activity of tumor demonstrated by expression of Ki-67 in breast cancer has been associated with a poor prognosis. Changes in the relative proportions of Ki-67 can be observed during chemotherapy and may correlated with clinical response in breast cancer. Purpose: Evaluate changes in mRNA expression of proliferation marker Ki-67 in breast cancer patients pre- and post-chemotherapy in relation with clinical response to chemotherapy. Method: This is a longitudinal study, 30 subjects breast cancer tissue samples pre- and post-chemotherapy using cyclophosphamide, adriamycin, 5FU regiment. We using qRT-PCR techniques to detect mRNA expression of Ki-67. Chemotherapy response is calculated using RECIST criteria. Results: Mean value of Ki-67 mRNA expression on breast cancer patients pre-chemotheraphy was 11.837±0.360. Mean value of Ki-67 mRNA expression on breast cancer patients post-chemotheraphy was 11.241±1.971. There was no significant correlation between expression of Ki-67 mRNA prechemotherapy with clinical response to chemotherapy, p = 0.862 (p ≥0.05). There is a positive correlation between velocity of Ki-67 mRNA expression with clinical response with value of r = 0.378, this correlation was significant with p = 0.020 (p<0.05). Conclusion: Chemotherapy cause decrease in mRNA expression of Ki-67. There is insignificant correlation between expression of mRNA Ki-67 baseline with chemotherapy response. Velocity of Ki-67 mRNA expression has significant correlation with clinical response to chemotherapy.
Abstract: Background: Proliferation is a distinct hallmarks of cancer. Ki-67 designated as a marker of proliferation in solid tumors. The proliferative activity of tumor demonstrated by expression of Ki-67 in breast cancer has been associated with a poor prognosis. Changes in the relative proportions of Ki-67 can be observed during chemotherapy and may corre...
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Drug Compliance in Children with Juvenile Idiopathic Arthritis and Reasons for Poor Compliance
Mohammad Humayun Kabir,
Kamrul Laila,
Mujammel Haque,
Shahana Akhter Rahman
Issue:
Volume 5, Issue 1, January 2017
Pages:
15-18
Received:
14 December 2016
Accepted:
27 December 2016
Published:
23 January 2017
Abstract: Children with chronic disorders are at risk for a higher medication non-adherence. Juvenile idiopathic arthritis (JIA) is a chronic childhood disorder where often medication non-adherence is an issue. The purpose of this study was to assess drug compliance of JIA patients,to find out the proportion of patients having poor drug compliance and to find out possible reasons of poor drug compliance. This was a retrospective study conducted in the Pediatric Rheumatology follow up clinic, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. All JIA patients attending pediatric rheumatology follow up clinic during the study period was included. Data were collected using a structured questionnaire. Among the total 900 registered JIA cases, 116(12.9%) patients had poor compliance. Among 116 poor compliant patients, systemic onset JIA cases were the highest (34.5%), followed by enthesitis related arthritis (30.2%). Among the poor compliant patients, 6.9% patients had regular follow up and 93.1% had irregular follow up. Major reasons of poor compliance were financial crisis, lack of awareness and difficulty in transportation. Poor compliance to treatment of JIA in our setting was common. The most important reason for poor compliance was financial crisis.
Abstract: Children with chronic disorders are at risk for a higher medication non-adherence. Juvenile idiopathic arthritis (JIA) is a chronic childhood disorder where often medication non-adherence is an issue. The purpose of this study was to assess drug compliance of JIA patients,to find out the proportion of patients having poor drug compliance and to fin...
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Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis
Xinan Wang,
Donghui Tian,
Jianfang Wang,
Xiuhe Ouyang
Issue:
Volume 5, Issue 1, January 2017
Pages:
19-25
Received:
9 February 2017
Published:
10 February 2017
Abstract: Subheading: Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD. Objective: The research aims to quantitatively evaluate the serum MMP-9, inhibitors of TIMP-1, TNF-α, and OPG/RANK/RANKL in the patients with COPD accompanied by osteoporosis. Method: We selected 90 male patients with stable phase COPD who received treatment in our hospital from September 2012 to May 2014. They were divided into three groups by bone mineral density (BMD), COPD normal bone mass group, low bone mass group, and osteoporosis group of 30 patients each. MMP-9, TIMP-1, TNF-α, and OPG/RANK/RANKL were detected with the ELISA method. The ELISA method was used to detect the levels of serum bone alkaline phosphatase (sBAP), serum osteocalcin (sOC), serum type I collagen cross-linked C telopeptide (sCTX). Result: There were significant differences in BMI and CAT scores between the osteoporosis group, the normal bone mass group, and the low bone mass group (P<0.01). The bone density of lumbar vertebra in the low bone mass group and the osteoporosis group decreased when compared with that in the normal bone mass group. The differences were statistically significant (P<0.05, P<0.01). The density of femoral neck in the low bone mass group and the osteoporosis group was significantly lower than that in the normal bone mass group. And there were significant differences (P<0.01). There were significant differences in level of serum MMP-9 among the three groups (P<0.01). Conclusion: MMP-9, TNF-α, and OPG/RANK/RANKL may play a collaborative role in occurrence and progression of pulmonary parenchyma damage and osteoporosis.
Abstract: Subheading: Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD. Objective: The research aims to quantitatively evaluate the serum MMP-9, inhibitors of TIMP-1, TNF-α, and OPG/RANK/RANKL in the patients with COPD accompanied by osteoporosis. Method: We selected 90 male patients with stable phase COPD who received treatment in our...
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Analysis of Nutritional Status and Levels of Sebum on Various Age Groups
Farida Tabri,
Ilhamjaya Patellongi,
Siswanto Wahab,
Khairuddin Djawad
Issue:
Volume 5, Issue 1, January 2017
Pages:
26-29
Received:
18 January 2017
Accepted:
3 February 2017
Published:
27 February 2017
Abstract: The effects of aging on skin physiology have been reported previously. In this study we tried to elucidate the correlation of skin types with age and nutritional status. There is a correlation between the age groups with nutritional status, correlation between age groups with the sebum levels on the forehead, and also there is a correlation between nutritional status and sebum level on forehead.
Abstract: The effects of aging on skin physiology have been reported previously. In this study we tried to elucidate the correlation of skin types with age and nutritional status. There is a correlation between the age groups with nutritional status, correlation between age groups with the sebum levels on the forehead, and also there is a correlation between...
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