Bioactive glass is a prominent biomaterial that can bind with both soft and hard tissues when in contact with body fluid. This study aims to find out how silicon concentration affects the cytotoxicity and bioactivity of bioactive glass. The 58S, 68S, and 76S BG particles were synthesized using a spray pyrolysis method. XRD, SEM, FTIR, and BET were used to examine the phase composition, morphology, chemical identity, and specific surface area of BG powders. The ability of the specimens to generate apatite on their surface after being soaked in the simulated body fluid (SBF) was determined using an in vitro test to measure their bioactivity. To evaluate the bioactivity of the BG powders, the in vitro apatite formation was investigated using XRD, FTIR, and SEM. Also, an in vitro cytotoxicity test was done using (MTT assay). A cell-growing environment was used to evaluate the in vitro cytotoxicity test based on different extraction concentrations of glass particles. The experimental results suggested that as silicon concentration in the BG increased, cell viability increased whereas bioactivity was reduced. Finally, the correlation between silicon content and cell viability and bioactivity was explored.
| Published in | Journal of Biomaterials (Volume 7, Issue 1) |
| DOI | 10.11648/j.jb.20230701.11 |
| Page(s) | 1-7 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Bioactive Glass, Bioactivity, Cytotoxicity, Silicon Concentration, Spray Pyrolysis
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APA Style
Chuni Aklilu, T., Gashaw Ewnete, B., Aboneh Mekuria, M., Aberra Tessema, A., Hadish, F., et al. (2023). Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass. Journal of Biomaterials, 7(1), 1-7. https://doi.org/10.11648/j.jb.20230701.11
ACS Style
Chuni Aklilu, T.; Gashaw Ewnete, B.; Aboneh Mekuria, M.; Aberra Tessema, A.; Hadish, F., et al. Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass. J. Biomater. 2023, 7(1), 1-7. doi: 10.11648/j.jb.20230701.11
AMA Style
Chuni Aklilu T, Gashaw Ewnete B, Aboneh Mekuria M, Aberra Tessema A, Hadish F, et al. Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass. J Biomater. 2023;7(1):1-7. doi: 10.11648/j.jb.20230701.11
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Download@article{10.11648/j.jb.20230701.11,
author = {Tsion Chuni Aklilu and Bethelhem Gashaw Ewnete and Megersa Aboneh Mekuria and Aster Aberra Tessema and Filimon Hadish and Fetene Fufa Bakare},
title = {Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass},
journal = {Journal of Biomaterials},
volume = {7},
number = {1},
pages = {1-7},
doi = {10.11648/j.jb.20230701.11},
url = {https://doi.org/10.11648/j.jb.20230701.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jb.20230701.11},
abstract = {Bioactive glass is a prominent biomaterial that can bind with both soft and hard tissues when in contact with body fluid. This study aims to find out how silicon concentration affects the cytotoxicity and bioactivity of bioactive glass. The 58S, 68S, and 76S BG particles were synthesized using a spray pyrolysis method. XRD, SEM, FTIR, and BET were used to examine the phase composition, morphology, chemical identity, and specific surface area of BG powders. The ability of the specimens to generate apatite on their surface after being soaked in the simulated body fluid (SBF) was determined using an in vitro test to measure their bioactivity. To evaluate the bioactivity of the BG powders, the in vitro apatite formation was investigated using XRD, FTIR, and SEM. Also, an in vitro cytotoxicity test was done using (MTT assay). A cell-growing environment was used to evaluate the in vitro cytotoxicity test based on different extraction concentrations of glass particles. The experimental results suggested that as silicon concentration in the BG increased, cell viability increased whereas bioactivity was reduced. Finally, the correlation between silicon content and cell viability and bioactivity was explored.
},
year = {2023}
}
TY - JOUR T1 - Investigation of the Effect of Silicon Concentration on Biocompatibility and Bioactivity of Spray Pyrolyzed Bioactive Glass AU - Tsion Chuni Aklilu AU - Bethelhem Gashaw Ewnete AU - Megersa Aboneh Mekuria AU - Aster Aberra Tessema AU - Filimon Hadish AU - Fetene Fufa Bakare Y1 - 2023/12/06 PY - 2023 N1 - https://doi.org/10.11648/j.jb.20230701.11 DO - 10.11648/j.jb.20230701.11 T2 - Journal of Biomaterials JF - Journal of Biomaterials JO - Journal of Biomaterials SP - 1 EP - 7 PB - Science Publishing Group SN - 2640-2629 UR - https://doi.org/10.11648/j.jb.20230701.11 AB - Bioactive glass is a prominent biomaterial that can bind with both soft and hard tissues when in contact with body fluid. This study aims to find out how silicon concentration affects the cytotoxicity and bioactivity of bioactive glass. The 58S, 68S, and 76S BG particles were synthesized using a spray pyrolysis method. XRD, SEM, FTIR, and BET were used to examine the phase composition, morphology, chemical identity, and specific surface area of BG powders. The ability of the specimens to generate apatite on their surface after being soaked in the simulated body fluid (SBF) was determined using an in vitro test to measure their bioactivity. To evaluate the bioactivity of the BG powders, the in vitro apatite formation was investigated using XRD, FTIR, and SEM. Also, an in vitro cytotoxicity test was done using (MTT assay). A cell-growing environment was used to evaluate the in vitro cytotoxicity test based on different extraction concentrations of glass particles. The experimental results suggested that as silicon concentration in the BG increased, cell viability increased whereas bioactivity was reduced. Finally, the correlation between silicon content and cell viability and bioactivity was explored. VL - 7 IS - 1 ER -
Department of Materials Science and Engineering, Adama Science and Technology University, Adama, Ethiopia; Department of Advanced Materials Science and Engineering Center of Excellence, Adama Science and Technology University, Adama, Ethiopia
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