Objective: The objective of this paper is to present, from a case, clinical parameters, imaging and anatomopathological assessments of the pulmonary squamous carcinomatous process in a non-smoking woman with a survival of more than 5 years. Case presentation: A 52-year-old patient who has had a pulmonary squamous carcinomatous process since 2014, revealed from a dry cough associated with mild dyspnoea without hemoptysis or chest pain. The imaging showed a left lung seat of two large masses, one of which extended towards the diaphragmatic dome, penetrating extensively into the abdomen, with a large abdominal contingent. Anatomopathological examination and the Immuno study -history -chemical evidence of a moderately differentiated squamous carcinoma infiltrating the lung. According to the TNM and AJCC 2016 classification, the patient was classified as T4N0M0 and she benefited from a navelbine cisplatin type chemotherapy with a minimal response of approximately 10% according to the RECIST criteria then two other lines of chemotherapy with initiation therapeutic pose. In 2019, she had a histologically confirmed metastatic relapse to the liver, treated with paclitaxel-carboplatin-type chemotherapy with clinical and radiological stability at assessment. Discussion: Squamous cell carcinoma is present in both smokers and non-smokers. Non-smoking females are two to three times more likely to develop lung cancer than non-smoking males, but female gender is a favourable risk factor. Conclusion: lung cancer in non-smoker females is becoming more and more frequent with genetic susceptibility as one of the etiological factors. The search for molecular alterations allows an increase in survival with the use of targeted therapies. Molecular biology is becoming an essential tool in the management of lung cancer with the presence of metastases.
| Published in | World Journal of Medical Case Reports (Volume 2, Issue 3) |
| DOI | 10.11648/j.wjmcr.20210203.15 |
| Page(s) | 51-54 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Squamous Cell, Lung, Non-smoking, Woman
| [1] | Huang Y, Wang R, Pan Y, Zhang Y, Li H, Cheng C, et al. Clinical and genetic features of lung squamous cell cancer in never-smokers. Oncotarget. 15 avr 2016; 7 (24): 35979-88. |
| [2] | Thiam K, Touré NO, Ndiaye EM, Baddredine H, Ndiaye M, Diop M, et al. Épidémiologie des cancers bronchopulmonaires primitifs des non-fumeurs au Sénégal. Rev Mal Respir. janv 2019; 36 (1): 15-21. |
| [3] | Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. févr 2010; 11 (2): 121-8. |
| [4] | Quoix É. Les nouveautés épidémiologiques du cancer bronchique: les non-fumeurs, les femmes, les fumeurs de cannabis. Rev Mal Respir. 1 oct 2007; 24 (8, Part 2): 10-5. |
| [5] | Sun Y, Ren Y, Fang Z, Li C, Fang R, Gao B, et al. Lung Adenocarcinoma From East Asian Never-Smokers Is a Disease Largely Defined by Targetable Oncogenic Mutant Kinases. J Clin Oncol. 20 oct 2010; 28 (30): 4616-20. |
| [6] | Zheng D, Wang R, Pan Y, Zheng S, Zhang Y, Li H, et al. Prevalence and Clinicopathological Characteristics of BRAF Mutations in Chinese Patients with Lung Adenocarcinoma. Ann Surg Oncol. déc 2015; 22 (S3): 1284-91. |
| [7] | Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, et al. Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers. JNCI J Natl Cancer Inst. 2 mars 2005; 97 (5): 339-46. |
| [8] | Shigematsu H, Takahashi T, Nomura M, Majmudar K, Suzuki M, Lee H, et al. Somatic Mutations of the HER2 Kinase Domain in Lung Adenocarcinomas. Cancer Res. 1 mars 2005; 65 (5): 1642-6. |
| [9] | Garrido P, Viñolas N, Isla D, Provencio M, Majem M, Artal A, et al. Lung cancer in Spanish women: The WORLD07 project. Eur J Cancer Care (Engl). janv 2019; 28 (1): e12941. |
| [10] | Debieuvre D, Locher C, Neidhardt A-C, Goupil F, Lemaire B, Blanchet-Legens A-S, et al. Évolution en 10ans du cancer bronchique non à petites cellules en fonction du sexe. Résultats de l’étude KBP-2010-CPHG du Collège des pneumologues des hôpitaux généraux. Rev Mal Respir. nov 2014; 31 (9): 805-16. |
| [11] | Miyamae Y, Shimizu K, Hirato J, Araki T, Tanaka K, Ogawa H, et al. Significance of epidermal growth factor receptor gene mutations in squamous cell lung carcinoma. Oncol Rep. avr 2011; 25 (4): 921-8. |
| [12] | Alberg AJ, Wallace K, Silvestri GA, Brock MV. Invited Commentary: The Etiology of Lung Cancer in Men Compared With Women. Am J Epidemiol. 1 avr 2013; 177 (7): 613-6. |
| [13] | Schwartz AG, Ray RM, Cote ML, Abrams J, Sokol RJ, Hendrix SL, et al. HORMONE USE, REPRODUCTIVE HISTORY AND RISK OF LUNG CANCER: THE WOMEN’S HEALTH INITIATIVE STUDIES. J Thorac Oncol Off Publ Int Assoc Study Lung Cancer. juill 2015; 10 (7): 1004-13. |
| [14] | Hadoux J, Besse B, Planchard D. Cancers bronchiques des non-fumeurs: particularités épidémiologiques, thérapeutiques et moléculaires. Presse Médicale. avr 2011; 40 (4): 371-8. |
| [15] | Janjigian YY, McDonnell K, Kris MG, Shen R, Sima CS, Bach PB, et al. Pack-years of cigarette smoking as a prognostic factor in patients with stage IIIB/IV nonsmall cell lung cancer. Cancer. 1 févr 2010; 116 (3): 670-5. |
| [16] | Mok TS, Wu Y-L, Thongprasert S, Yang C-H, Chu D-T, Saijo N, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 3 sept 2009; 361 (10): 947-57. |
| [17] | Harichand-Herdt S, Ramalingam SS. Gender-associated differences in lung cancer: clinical characteristics and treatment outcomes in women. Semin Oncol. déc 2009; 36 (6): 572-80. |
APA Style
Zongo Esdras, Khoaya Ayoub, Sidki Sanaa, Kaddouri Hajar, Talib Hatim, et al. (2021). Squamous Cell Lung Cancer in a Non-smoking Woman: A Case Report with Review of the Literature. World Journal of Medical Case Reports, 2(3), 51-54. https://doi.org/10.11648/j.wjmcr.20210203.15
ACS Style
Zongo Esdras; Khoaya Ayoub; Sidki Sanaa; Kaddouri Hajar; Talib Hatim, et al. Squamous Cell Lung Cancer in a Non-smoking Woman: A Case Report with Review of the Literature. World J. Med. Case Rep. 2021, 2(3), 51-54. doi: 10.11648/j.wjmcr.20210203.15
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Download@article{10.11648/j.wjmcr.20210203.15,
author = {Zongo Esdras and Khoaya Ayoub and Sidki Sanaa and Kaddouri Hajar and Talib Hatim and Chekrine Tarek and Bourhafour Mouna and Bouchbika Zineb and Benchakroun Nadia and Jouhadi Hassan and Sahraoui Souha and Karkouri Mehdi and Tawfik Nezha and Benider Abdellatif},
title = {Squamous Cell Lung Cancer in a Non-smoking Woman: A Case Report with Review of the Literature},
journal = {World Journal of Medical Case Reports},
volume = {2},
number = {3},
pages = {51-54},
doi = {10.11648/j.wjmcr.20210203.15},
url = {https://doi.org/10.11648/j.wjmcr.20210203.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjmcr.20210203.15},
abstract = {Objective: The objective of this paper is to present, from a case, clinical parameters, imaging and anatomopathological assessments of the pulmonary squamous carcinomatous process in a non-smoking woman with a survival of more than 5 years. Case presentation: A 52-year-old patient who has had a pulmonary squamous carcinomatous process since 2014, revealed from a dry cough associated with mild dyspnoea without hemoptysis or chest pain. The imaging showed a left lung seat of two large masses, one of which extended towards the diaphragmatic dome, penetrating extensively into the abdomen, with a large abdominal contingent. Anatomopathological examination and the Immuno study -history -chemical evidence of a moderately differentiated squamous carcinoma infiltrating the lung. According to the TNM and AJCC 2016 classification, the patient was classified as T4N0M0 and she benefited from a navelbine cisplatin type chemotherapy with a minimal response of approximately 10% according to the RECIST criteria then two other lines of chemotherapy with initiation therapeutic pose. In 2019, she had a histologically confirmed metastatic relapse to the liver, treated with paclitaxel-carboplatin-type chemotherapy with clinical and radiological stability at assessment. Discussion: Squamous cell carcinoma is present in both smokers and non-smokers. Non-smoking females are two to three times more likely to develop lung cancer than non-smoking males, but female gender is a favourable risk factor. Conclusion: lung cancer in non-smoker females is becoming more and more frequent with genetic susceptibility as one of the etiological factors. The search for molecular alterations allows an increase in survival with the use of targeted therapies. Molecular biology is becoming an essential tool in the management of lung cancer with the presence of metastases.},
year = {2021}
}
TY - JOUR T1 - Squamous Cell Lung Cancer in a Non-smoking Woman: A Case Report with Review of the Literature AU - Zongo Esdras AU - Khoaya Ayoub AU - Sidki Sanaa AU - Kaddouri Hajar AU - Talib Hatim AU - Chekrine Tarek AU - Bourhafour Mouna AU - Bouchbika Zineb AU - Benchakroun Nadia AU - Jouhadi Hassan AU - Sahraoui Souha AU - Karkouri Mehdi AU - Tawfik Nezha AU - Benider Abdellatif Y1 - 2021/08/27 PY - 2021 N1 - https://doi.org/10.11648/j.wjmcr.20210203.15 DO - 10.11648/j.wjmcr.20210203.15 T2 - World Journal of Medical Case Reports JF - World Journal of Medical Case Reports JO - World Journal of Medical Case Reports SP - 51 EP - 54 PB - Science Publishing Group SN - 2994-726X UR - https://doi.org/10.11648/j.wjmcr.20210203.15 AB - Objective: The objective of this paper is to present, from a case, clinical parameters, imaging and anatomopathological assessments of the pulmonary squamous carcinomatous process in a non-smoking woman with a survival of more than 5 years. Case presentation: A 52-year-old patient who has had a pulmonary squamous carcinomatous process since 2014, revealed from a dry cough associated with mild dyspnoea without hemoptysis or chest pain. The imaging showed a left lung seat of two large masses, one of which extended towards the diaphragmatic dome, penetrating extensively into the abdomen, with a large abdominal contingent. Anatomopathological examination and the Immuno study -history -chemical evidence of a moderately differentiated squamous carcinoma infiltrating the lung. According to the TNM and AJCC 2016 classification, the patient was classified as T4N0M0 and she benefited from a navelbine cisplatin type chemotherapy with a minimal response of approximately 10% according to the RECIST criteria then two other lines of chemotherapy with initiation therapeutic pose. In 2019, she had a histologically confirmed metastatic relapse to the liver, treated with paclitaxel-carboplatin-type chemotherapy with clinical and radiological stability at assessment. Discussion: Squamous cell carcinoma is present in both smokers and non-smokers. Non-smoking females are two to three times more likely to develop lung cancer than non-smoking males, but female gender is a favourable risk factor. Conclusion: lung cancer in non-smoker females is becoming more and more frequent with genetic susceptibility as one of the etiological factors. The search for molecular alterations allows an increase in survival with the use of targeted therapies. Molecular biology is becoming an essential tool in the management of lung cancer with the presence of metastases. VL - 2 IS - 3 ER -
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