Schiff-base ligands and their metal complexes are attracting a lot of research in bioinorganic and medicinal chemistry owing to their improved activity in biological systems. Six schiff-base ligands derived from amino acids; N-Salicylidene Alanine, N-Salicylidene Serine, N-Benzalidene Histidine, N-Balzalidene Leucine, N-4-(dimethylamino) benzalidene Phenylalanine, and N-4-(dimethylamino)benzalidene Valine have been synthesized, characterized and their bacterial growth inhibitory properties determined against Staphylococcus aureus and Escherichia coli. These schiff-bases are synthesized by the condensation reaction between carbonyl compounds (aldehydes and ketones) and amines (amino acids). Characterization of the schiff-base ligands is done using melting/decomposition temperatures, FTIR spectroscopy, US-visible spectroscopy, and solubility. It is observed that, all the schiff-base ligands contain the imine or azomethine (C=N) group with a stretching frequency ranging from 2200 - 2400 cm-1. In addition, all the schiff-base ligands are seen to be soluble in water, which is paramount in their application in biological systems. The structures of the schiff-base ligands were deduced based on the characterization techniques. Furthermore, the bacterial growth inhibitory properties of the schiff-base ligands were done using the Agar Well Diffusion method. The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria.
Published in | Science Journal of Chemistry (Volume 8, Issue 1) |
DOI | 10.11648/j.sjc.20200801.11 |
Page(s) | 1-6 |
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Amino Acids, Characterization, Schiff-Bases, Synthesis, Biological Activities, Imine Group
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APA Style
James Tembei Titah, Coulibaly Wacothon Karime, Kevin Chambers, Anita Balogh, Kevin Joannou. (2020). Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids. Science Journal of Chemistry, 8(1), 1-6. https://doi.org/10.11648/j.sjc.20200801.11
ACS Style
James Tembei Titah; Coulibaly Wacothon Karime; Kevin Chambers; Anita Balogh; Kevin Joannou. Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids. Sci. J. Chem. 2020, 8(1), 1-6. doi: 10.11648/j.sjc.20200801.11
AMA Style
James Tembei Titah, Coulibaly Wacothon Karime, Kevin Chambers, Anita Balogh, Kevin Joannou. Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids. Sci J Chem. 2020;8(1):1-6. doi: 10.11648/j.sjc.20200801.11
@article{10.11648/j.sjc.20200801.11, author = {James Tembei Titah and Coulibaly Wacothon Karime and Kevin Chambers and Anita Balogh and Kevin Joannou}, title = {Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids}, journal = {Science Journal of Chemistry}, volume = {8}, number = {1}, pages = {1-6}, doi = {10.11648/j.sjc.20200801.11}, url = {https://doi.org/10.11648/j.sjc.20200801.11}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20200801.11}, abstract = {Schiff-base ligands and their metal complexes are attracting a lot of research in bioinorganic and medicinal chemistry owing to their improved activity in biological systems. Six schiff-base ligands derived from amino acids; N-Salicylidene Alanine, N-Salicylidene Serine, N-Benzalidene Histidine, N-Balzalidene Leucine, N-4-(dimethylamino) benzalidene Phenylalanine, and N-4-(dimethylamino)benzalidene Valine have been synthesized, characterized and their bacterial growth inhibitory properties determined against Staphylococcus aureus and Escherichia coli. These schiff-bases are synthesized by the condensation reaction between carbonyl compounds (aldehydes and ketones) and amines (amino acids). Characterization of the schiff-base ligands is done using melting/decomposition temperatures, FTIR spectroscopy, US-visible spectroscopy, and solubility. It is observed that, all the schiff-base ligands contain the imine or azomethine (C=N) group with a stretching frequency ranging from 2200 - 2400 cm-1. In addition, all the schiff-base ligands are seen to be soluble in water, which is paramount in their application in biological systems. The structures of the schiff-base ligands were deduced based on the characterization techniques. Furthermore, the bacterial growth inhibitory properties of the schiff-base ligands were done using the Agar Well Diffusion method. The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria.}, year = {2020} }
TY - JOUR T1 - Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids AU - James Tembei Titah AU - Coulibaly Wacothon Karime AU - Kevin Chambers AU - Anita Balogh AU - Kevin Joannou Y1 - 2020/03/02 PY - 2020 N1 - https://doi.org/10.11648/j.sjc.20200801.11 DO - 10.11648/j.sjc.20200801.11 T2 - Science Journal of Chemistry JF - Science Journal of Chemistry JO - Science Journal of Chemistry SP - 1 EP - 6 PB - Science Publishing Group SN - 2330-099X UR - https://doi.org/10.11648/j.sjc.20200801.11 AB - Schiff-base ligands and their metal complexes are attracting a lot of research in bioinorganic and medicinal chemistry owing to their improved activity in biological systems. Six schiff-base ligands derived from amino acids; N-Salicylidene Alanine, N-Salicylidene Serine, N-Benzalidene Histidine, N-Balzalidene Leucine, N-4-(dimethylamino) benzalidene Phenylalanine, and N-4-(dimethylamino)benzalidene Valine have been synthesized, characterized and their bacterial growth inhibitory properties determined against Staphylococcus aureus and Escherichia coli. These schiff-bases are synthesized by the condensation reaction between carbonyl compounds (aldehydes and ketones) and amines (amino acids). Characterization of the schiff-base ligands is done using melting/decomposition temperatures, FTIR spectroscopy, US-visible spectroscopy, and solubility. It is observed that, all the schiff-base ligands contain the imine or azomethine (C=N) group with a stretching frequency ranging from 2200 - 2400 cm-1. In addition, all the schiff-base ligands are seen to be soluble in water, which is paramount in their application in biological systems. The structures of the schiff-base ligands were deduced based on the characterization techniques. Furthermore, the bacterial growth inhibitory properties of the schiff-base ligands were done using the Agar Well Diffusion method. The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria. VL - 8 IS - 1 ER -