There are two problems that hinder the use of double emulsions in pharmacies: large-scale equipment not available for one-step emulsification and obtaining a double emulsion and limited ingredients available to replace the tension-active agents as primary emulsifier because these surfactants are toxic. To overcome these difficulties, a two-stage emulsification strategy has been developed, first generating a water-in-oil Pickering emulsion stabilized by magnesium oxide particles and then the double W/O/W emulsion, thereby reducing significantly the amount of voltage-active. Pickering emulsions are surfactant-free emulsions, stabilized by colloidal particles. These systems are experiencing renewed interest on the one hand, because it is preferable to limit the use of synthetic surfactants for ecological reasons, and on the other hand, because the functionalization of particles has undergone recent advances. It is possible to make very simple calibrated emulsions of controlled size, exploiting a phenomenon called "limited coalescence". The Bancroft rule served as a model for the formulation. The emulsification was carried out using a rotor stator mixer. The stability of these emulsions has been studied using several parameters (pH, conductivity, droplet size, dye test). The dye test and the conductivity measurement confirmed the W/O nature of the emulsion and W/O/W nature of the double emulsion. This study showed that we were able to develop a saturated double W/O/W emulsion.
| Published in | Pharmaceutical Science and Technology (Volume 4, Issue 2) |
| DOI | 10.11648/j.pst.20200402.11 |
| Page(s) | 25-30 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Pickering, Double Emulsion, Magnesium Oxide
| [1] | Pickering SU. CXCVI.—Emulsions. J Chem Soc Trans. 1907; 91: 2001–21. |
| [2] | Abismaïl B, Canselier JP, Wilhelm AM, Delmas H, Gourdon C. Emulsification by ultrasound: drop size distribution and stability. Ultrason Sonochem. 1999; 6: 75–83. |
| [3] | Dieng SM, Soumboundou M, Sy PM, MohamedWane T, Djiboune AR, Diouf LAD, et al. Formulation and Evaluation of Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles Containing Paracetamol in the Internal Phase. ARC J Pharm Sci. ARC Journals; 2019; 5: 34–42. |
| [4] | Frelichowska J, Bolzinger M-A, Chevalier Y. Effects of solid particle content on properties of o/w Pickering emulsions. J Colloid Interface Sci. 2010; 351: 348–56. |
| [5] | Kim J-H, Kim S-E, Kyong K-Y, Lee E-J, Cho W-G, Yoon M-S. Effect of aqueous phase composition on the stability of a silica-stabilized water-in-oil emulsion. J Soc Cosmet Sci Korea. 2004; 30. |
| [6] | Linke C, Drusch S. Pickering emulsions in foods - opportunities and limitations. Crit Rev Food Sci Nutr. 2018; 58: 1971–85. |
| [7] | Altuntas OY, Sumnu G, Sahin S. Preparation and characterization of W/O/W type double emulsion containing PGPR–lecithin mixture as lipophilic surfactant. J Dispers Sci Technol. Taylor & Francis; 2017; 38: 486–93. |
| [8] | Spyropoulos F, Duffus LJ, Smith P, Norton IT. Impact of Pickering Intervention on the Stability of W1/O/W2 Double Emulsions of Relevance to Foods. Langmuir. American Chemical Society; 2019; 35: 15137–50. |
| [9] | Devanthi PVP, Linforth R, El Kadri H, Gkatzionis K. Water-in-oil-in-water double emulsion for the delivery of starter cultures in reduced-salt moromi fermentation of soy sauce. Food Chem. 2018; 257: 243–51. |
| [10] | Devanthi PVP, El Kadri H, Bowden A, Spyropoulos F, Gkatzionis K. Segregation of Tetragenococcus halophilus and Zygosaccharomyces rouxii using W1/O/W2 double emulsion for use in mixed culture fermentation. Food Res Int. 2018; 105: 333–43. |
| [11] | Diouf LA, Mbaye G, Ndiaye A, Diarra M. Peanut oil based W1/o/W2 multiple emulsions for oral administration of insulin | International Journal of Current Research [Internet]. 2015. Available from: https: //www.journalcra.com/article/peanut-oil-based-w1ow2-multiple-emulsions-oral-administration-insulin. |
| [12] | Zhu Q, Qiu S, Zhang H, Cheng Y, Yin L. Physical stability, microstructure and micro-rheological properties of water-in-oil-in-water (W/O/W) emulsions stabilized by porcine gelatin. Food Chem. 2018; 253: 63–70. |
| [13] | Balcão VM, Glasser CA, Chaud MV, Vila MMDC. Chapter 6 - Water-in-Oil-in-Water Nanoencapsulation Systems. In: Sagis LMC, editor. Microencapsul Microspheres Food Appl [Internet]. San Diego: Academic Press; 2015 [cited 2020 Jun 26]. p. 95–129. Available from: http://www.sciencedirect.com/science/article/pii/B978012800350300008X. |
| [14] | Blanco ME, Gallo JAQ, Arias KSE, Islas RP. Colorimetry Technique as a Tool for Determining Release Kinetics and Mass Transfer Parameters of Anthocyanins Encapsulated in W1/O/W2 Double Emulsions. Int J Food Eng. De Gruyter; 2016; 12: 615–24. |
| [15] | Ding S, Serra CA, Vandamme TF, Yu W, Anton N. Double emulsions prepared by two–step emulsification: History, state-of-the-art and perspective. J Controlled Release. 2019; 295: 31–49. |
| [16] | Eslami P, Davarpanah L, Vahabzadeh F. Encapsulating role of β-cyclodextrin in formation of pickering water-in-oil-in-water (W1/O/W2) double emulsions containing Lactobacillus dellbrueckii. Food Hydrocoll. 2017; 64: 133–48. |
| [17] | Kini GC, Biswal SL, Wong MS. Non-LBL Assembly and Encapsulation Uses of Nanoparticle-Shelled Hollow Spheres. 2010. |
| [18] | Theron F. Conception et mise en œuvre d’un procédé intensifié continu de microencapsulation par polycondensation interfaciale [Internet] [phd]. 2009 [cited 2019 Oct 14]. Available from: http://ethesis.inp-toulouse.fr/archive/00001225/. |
| [19] | Begbeg A. Importance des considérations environnementales dans l’étude des performances des additifs utilises dans les fluides de forage [Internet] [Thesis]. 2008 [cited 2019 Oct 14]. Available from: http://192.168.100.2: 8080//handle/123456789/1106. |
| [20] | Yan Y, Masliyah JH. Solids-stabilized oil-in-water emulsions: Scavenging of emulsion droplets by fresh oil addition. Colloids Surf Physicochem Eng Asp. 1993; 75: 123–32. |
| [21] | Fouilloux S. Nanoparticules et microfluidique pour un système modèle d’émulsions de Pickering. Etude des mécanismes de stabilisation et déstabilisation. 2011; 248. |
| [22] | Vignati E, Piazza R, Lockhart TP. Pickering Emulsions: Interfacial Tension, Colloidal Layer Morphology, and Trapped-Particle Motion. Langmuir. 2003; 19: 6650–6. |
| [23] | Tarimala S, Dai LL. Structure of Microparticles in Solid-Stabilized Emulsions. Langmuir. 2004; 20: 3492–4. |
| [24] | Yang F, Niu Q, Lan Q, Sun D. Effect of dispersion pH on the formation and stability of Pickering emulsions stabilized by layered double hydroxides particles. J Colloid Interface Sci. 2007; 306: 285–95. |
APA Style
Sidy Mouhamed Dieng, Louis Augustin Diaga Diouf, Alphonse Rodrigue Djiboune, Papa Mady Sy, Mamadou Soumboundou, et al. (2020). Water in Oil W/O Pickering Emulsion Encapsulated in Oil in Water O/W Emulsion: A Double Emulsion for Poorly Soluble Drugs. Pharmaceutical Science and Technology, 4(2), 25-30. https://doi.org/10.11648/j.pst.20200402.11
ACS Style
Sidy Mouhamed Dieng; Louis Augustin Diaga Diouf; Alphonse Rodrigue Djiboune; Papa Mady Sy; Mamadou Soumboundou, et al. Water in Oil W/O Pickering Emulsion Encapsulated in Oil in Water O/W Emulsion: A Double Emulsion for Poorly Soluble Drugs. Pharm. Sci. Technol. 2020, 4(2), 25-30. doi: 10.11648/j.pst.20200402.11
AMA Style
Sidy Mouhamed Dieng, Louis Augustin Diaga Diouf, Alphonse Rodrigue Djiboune, Papa Mady Sy, Mamadou Soumboundou, et al. Water in Oil W/O Pickering Emulsion Encapsulated in Oil in Water O/W Emulsion: A Double Emulsion for Poorly Soluble Drugs. Pharm Sci Technol. 2020;4(2):25-30. doi: 10.11648/j.pst.20200402.11
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.pst.20200402.11,
author = {Sidy Mouhamed Dieng and Louis Augustin Diaga Diouf and Alphonse Rodrigue Djiboune and Papa Mady Sy and Mamadou Soumboundou and Djibril Kebe and Gora Mbaye and Oumar Thioune and Mounibe Diarra},
title = {Water in Oil W/O Pickering Emulsion Encapsulated in Oil in Water O/W Emulsion: A Double Emulsion for Poorly Soluble Drugs},
journal = {Pharmaceutical Science and Technology},
volume = {4},
number = {2},
pages = {25-30},
doi = {10.11648/j.pst.20200402.11},
url = {https://doi.org/10.11648/j.pst.20200402.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20200402.11},
abstract = {There are two problems that hinder the use of double emulsions in pharmacies: large-scale equipment not available for one-step emulsification and obtaining a double emulsion and limited ingredients available to replace the tension-active agents as primary emulsifier because these surfactants are toxic. To overcome these difficulties, a two-stage emulsification strategy has been developed, first generating a water-in-oil Pickering emulsion stabilized by magnesium oxide particles and then the double W/O/W emulsion, thereby reducing significantly the amount of voltage-active. Pickering emulsions are surfactant-free emulsions, stabilized by colloidal particles. These systems are experiencing renewed interest on the one hand, because it is preferable to limit the use of synthetic surfactants for ecological reasons, and on the other hand, because the functionalization of particles has undergone recent advances. It is possible to make very simple calibrated emulsions of controlled size, exploiting a phenomenon called "limited coalescence". The Bancroft rule served as a model for the formulation. The emulsification was carried out using a rotor stator mixer. The stability of these emulsions has been studied using several parameters (pH, conductivity, droplet size, dye test). The dye test and the conductivity measurement confirmed the W/O nature of the emulsion and W/O/W nature of the double emulsion. This study showed that we were able to develop a saturated double W/O/W emulsion.},
year = {2020}
}
TY - JOUR T1 - Water in Oil W/O Pickering Emulsion Encapsulated in Oil in Water O/W Emulsion: A Double Emulsion for Poorly Soluble Drugs AU - Sidy Mouhamed Dieng AU - Louis Augustin Diaga Diouf AU - Alphonse Rodrigue Djiboune AU - Papa Mady Sy AU - Mamadou Soumboundou AU - Djibril Kebe AU - Gora Mbaye AU - Oumar Thioune AU - Mounibe Diarra Y1 - 2020/11/30 PY - 2020 N1 - https://doi.org/10.11648/j.pst.20200402.11 DO - 10.11648/j.pst.20200402.11 T2 - Pharmaceutical Science and Technology JF - Pharmaceutical Science and Technology JO - Pharmaceutical Science and Technology SP - 25 EP - 30 PB - Science Publishing Group SN - 2640-4540 UR - https://doi.org/10.11648/j.pst.20200402.11 AB - There are two problems that hinder the use of double emulsions in pharmacies: large-scale equipment not available for one-step emulsification and obtaining a double emulsion and limited ingredients available to replace the tension-active agents as primary emulsifier because these surfactants are toxic. To overcome these difficulties, a two-stage emulsification strategy has been developed, first generating a water-in-oil Pickering emulsion stabilized by magnesium oxide particles and then the double W/O/W emulsion, thereby reducing significantly the amount of voltage-active. Pickering emulsions are surfactant-free emulsions, stabilized by colloidal particles. These systems are experiencing renewed interest on the one hand, because it is preferable to limit the use of synthetic surfactants for ecological reasons, and on the other hand, because the functionalization of particles has undergone recent advances. It is possible to make very simple calibrated emulsions of controlled size, exploiting a phenomenon called "limited coalescence". The Bancroft rule served as a model for the formulation. The emulsification was carried out using a rotor stator mixer. The stability of these emulsions has been studied using several parameters (pH, conductivity, droplet size, dye test). The dye test and the conductivity measurement confirmed the W/O nature of the emulsion and W/O/W nature of the double emulsion. This study showed that we were able to develop a saturated double W/O/W emulsion. VL - 4 IS - 2 ER -
Information
Email: