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Study on the Correlation Between ANCA and Thyroid-related Ophthalmopathy

Received: 16 December 2019     Accepted: 2 January 2020     Published: 17 January 2020
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Abstract

Background The pathogenesis of thyroid associated ophthalmopathy (TAO) is still unclear. Studies have proved that there are several autoantibodies in TAO patients, and ANCA, as one of the autoantibodies, is positive in some TAO patients, but its correlation with the occurrence, development and outcome of TAO is still unclear. Objective To study the correlation between ANCA and Thyroid Associated Ophthalmopathy. Methods Prospective observational cohort study was designed. This study was approved by the Ethic Commission of Hunan Provincial People’s Hospital/the First Affiliated Hospital of Hunan Normal University, and written informed consent was obtained from each Subject before entering this trial. 120 patients diagnosed as TAO and visited our hospital from January 2016 to June 2018 were enrolled in the study, including 30 cases in inactive group and 90 cases in active group [According to the criteria of clinical activity score (CAS)], 42 cases in Mild group and 78 cases in Moderate-to-severe and Sight-threatening group (According to the criteria of EUGOGO). The differences in ANCA positive rate among above groups and Active group after transferred to Inactive were compared. Results The overall positive rate of ANCA in TAO patients was 16.7%. The positive rates in the Inactive group and Active group were respectively 3.33% and 21.11%, and the difference was statistically significant (P<0.05). The positive rates of Mild group, Moderate-to-severe group and Sight-threatening group were respectively 8.82% and 19.76%, and there was no significant differences statistically (P>0.05). The positive rates of Active group reduced to 5.5%, and the difference was statistically significant (P<0.05). Conclusion ANCA can reflects the activity of TAO to some extent, which is helpful to guide clinical treatment and prognosis judgment.

Published in International Journal of Ophthalmology & Visual Science (Volume 5, Issue 1)
DOI 10.11648/j.ijovs.20200501.14
Page(s) 21-23
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Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Antineutrophil Cytoplasmic Antibody, Thyroid Associated Ophthalmopathy, Correlation

References
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[3] Fu Dian, Liu Yi, Wang Jian. Research progress on thyroid-related ophthalmopathy and autoantigens [J]. Medical Review, 2012, 18 (9): 1374-1376. DOI: 10.3969/j.issn.1006-2084.2012.09.035.
[4] Feng Xiaoting, Li Zhangfang, Shen Jie: Progress in the diagnosis and treatment of thyroid-related ophthalmopathy. [J]. Chinese Journal of Practical Internal Medicine 2019, 39 (04): 384-388.
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[7] Bartalena L, Baldeschi L, Boboridis K. The 2016 European Thyroid Association/European Group on Graves’ Orbitopathy Guidelines for the Management of Graves Orbitopathy [J]. Eur Thyroid J, 2016, 5 (1): 9-26. DOI: 10.1159/000443828.
[8] Tan Liming, Jiao Anjun, Feng Xiaojing, Xu Yanyue, Tan Fuyan, He Siqi, Luo Yan, Chen Juanjuan, Jiang Yongqing, Li Hua: Clinical value of antineutrophil cytoplasmic antibody detection for systemic vasculitis. [J]. Laboratory Medicine 2018, 33 (02): 101-105.
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[10] Dolman KM, Gans RO, Vervaat TJ, et al. Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy [J]. Lancet, 1993:, 342: 651-652. DOI: 10.1016/0140-6736(93)91761-A.
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    Yuping Xiong, Changfu Peng. (2020). Study on the Correlation Between ANCA and Thyroid-related Ophthalmopathy. International Journal of Ophthalmology & Visual Science, 5(1), 21-23. https://doi.org/10.11648/j.ijovs.20200501.14

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    ACS Style

    Yuping Xiong; Changfu Peng. Study on the Correlation Between ANCA and Thyroid-related Ophthalmopathy. Int. J. Ophthalmol. Vis. Sci. 2020, 5(1), 21-23. doi: 10.11648/j.ijovs.20200501.14

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    AMA Style

    Yuping Xiong, Changfu Peng. Study on the Correlation Between ANCA and Thyroid-related Ophthalmopathy. Int J Ophthalmol Vis Sci. 2020;5(1):21-23. doi: 10.11648/j.ijovs.20200501.14

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  • @article{10.11648/j.ijovs.20200501.14,
      author = {Yuping Xiong and Changfu Peng},
      title = {Study on the Correlation Between ANCA and Thyroid-related Ophthalmopathy},
      journal = {International Journal of Ophthalmology & Visual Science},
      volume = {5},
      number = {1},
      pages = {21-23},
      doi = {10.11648/j.ijovs.20200501.14},
      url = {https://doi.org/10.11648/j.ijovs.20200501.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20200501.14},
      abstract = {Background The pathogenesis of thyroid associated ophthalmopathy (TAO) is still unclear. Studies have proved that there are several autoantibodies in TAO patients, and ANCA, as one of the autoantibodies, is positive in some TAO patients, but its correlation with the occurrence, development and outcome of TAO is still unclear. Objective To study the correlation between ANCA and Thyroid Associated Ophthalmopathy. Methods Prospective observational cohort study was designed. This study was approved by the Ethic Commission of Hunan Provincial People’s Hospital/the First Affiliated Hospital of Hunan Normal University, and written informed consent was obtained from each Subject before entering this trial. 120 patients diagnosed as TAO and visited our hospital from January 2016 to June 2018 were enrolled in the study, including 30 cases in inactive group and 90 cases in active group [According to the criteria of clinical activity score (CAS)], 42 cases in Mild group and 78 cases in Moderate-to-severe and Sight-threatening group (According to the criteria of EUGOGO). The differences in ANCA positive rate among above groups and Active group after transferred to Inactive were compared. Results The overall positive rate of ANCA in TAO patients was 16.7%. The positive rates in the Inactive group and Active group were respectively 3.33% and 21.11%, and the difference was statistically significant (PP>0.05). The positive rates of Active group reduced to 5.5%, and the difference was statistically significant (P<0.05). Conclusion ANCA can reflects the activity of TAO to some extent, which is helpful to guide clinical treatment and prognosis judgment.},
     year = {2020}
    }
    

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    T1  - Study on the Correlation Between ANCA and Thyroid-related Ophthalmopathy
    AU  - Yuping Xiong
    AU  - Changfu Peng
    Y1  - 2020/01/17
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    DO  - 10.11648/j.ijovs.20200501.14
    T2  - International Journal of Ophthalmology & Visual Science
    JF  - International Journal of Ophthalmology & Visual Science
    JO  - International Journal of Ophthalmology & Visual Science
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    PB  - Science Publishing Group
    SN  - 2637-3858
    UR  - https://doi.org/10.11648/j.ijovs.20200501.14
    AB  - Background The pathogenesis of thyroid associated ophthalmopathy (TAO) is still unclear. Studies have proved that there are several autoantibodies in TAO patients, and ANCA, as one of the autoantibodies, is positive in some TAO patients, but its correlation with the occurrence, development and outcome of TAO is still unclear. Objective To study the correlation between ANCA and Thyroid Associated Ophthalmopathy. Methods Prospective observational cohort study was designed. This study was approved by the Ethic Commission of Hunan Provincial People’s Hospital/the First Affiliated Hospital of Hunan Normal University, and written informed consent was obtained from each Subject before entering this trial. 120 patients diagnosed as TAO and visited our hospital from January 2016 to June 2018 were enrolled in the study, including 30 cases in inactive group and 90 cases in active group [According to the criteria of clinical activity score (CAS)], 42 cases in Mild group and 78 cases in Moderate-to-severe and Sight-threatening group (According to the criteria of EUGOGO). The differences in ANCA positive rate among above groups and Active group after transferred to Inactive were compared. Results The overall positive rate of ANCA in TAO patients was 16.7%. The positive rates in the Inactive group and Active group were respectively 3.33% and 21.11%, and the difference was statistically significant (PP>0.05). The positive rates of Active group reduced to 5.5%, and the difference was statistically significant (P<0.05). Conclusion ANCA can reflects the activity of TAO to some extent, which is helpful to guide clinical treatment and prognosis judgment.
    VL  - 5
    IS  - 1
    ER  - 

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Author Information
  • Department of Ophthalmology, The First Affiliated Hospital of Hunan Normal University/Hunan Provincial People’s Hospital, Changsha, China

  • Department of Ophthalmology, Hunan Provincial People’s Hospital/The First Affiliated Hospital of Hunan Normal University, Changsha, China

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