The effect of high fat diet on lipid and carbohydrate metabolic changes was studied in mature male albino rats. The animals were rendered obese by feeding a high fat diet for 60 days. Half of obese rats were become diabetic by injecting with a reduced dose of alloxan; to produce a non insulin dependent diabetes mellitus state. These obese models of non diabetic and diabetic rats were compared with normal male rats kept on a basal diet for 60 days. The fat fed rats beside gaining weight showed a significant rise in their hepatic lipid contents and observed an insulin resistant state. Lipid profile of the omental adipose tissue exhibited a significantly higher total lipid content, but lower total cholesterol, triglycerides and phospholipids contents in both obese (non diabetic and diabetic) as compared with the normal rats. On the other hand, the brown adipose tissue showed a reduced fat catabolism with a significant rise in its phospholipid contents. Correlation between plasma atherogenic index and plasma fatty acids pattern showed that in the obese diabetic rats atherogenic index was positively correlated with total polyunsaturated fatty acids, while significantly negative correlation with total saturated fatty acids. This work showed that high fat substrates have been got remarkable impacts on rats body weight and metabolism.
Published in | International Journal of Nutrition and Food Sciences (Volume 2, Issue 2) |
DOI | 10.11648/j.ijnfs.20130202.11 |
Page(s) | 24-30 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2013. Published by Science Publishing Group |
Obesity, Diabetes, Male Albino Rats
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APA Style
Mostafa M. Osfor, Osama Kensarah, Firas Azzeh, Mohammad A. Elmadbouly, Mona El-Qutry. (2013). Biochemical Changes in LIPID and Car-bohydrate Metabolism in Obese Diabetic Male Albino Rats. International Journal of Nutrition and Food Sciences, 2(2), 24-30. https://doi.org/10.11648/j.ijnfs.20130202.11
ACS Style
Mostafa M. Osfor; Osama Kensarah; Firas Azzeh; Mohammad A. Elmadbouly; Mona El-Qutry. Biochemical Changes in LIPID and Car-bohydrate Metabolism in Obese Diabetic Male Albino Rats. Int. J. Nutr. Food Sci. 2013, 2(2), 24-30. doi: 10.11648/j.ijnfs.20130202.11
AMA Style
Mostafa M. Osfor, Osama Kensarah, Firas Azzeh, Mohammad A. Elmadbouly, Mona El-Qutry. Biochemical Changes in LIPID and Car-bohydrate Metabolism in Obese Diabetic Male Albino Rats. Int J Nutr Food Sci. 2013;2(2):24-30. doi: 10.11648/j.ijnfs.20130202.11
@article{10.11648/j.ijnfs.20130202.11, author = {Mostafa M. Osfor and Osama Kensarah and Firas Azzeh and Mohammad A. Elmadbouly and Mona El-Qutry}, title = {Biochemical Changes in LIPID and Car-bohydrate Metabolism in Obese Diabetic Male Albino Rats}, journal = {International Journal of Nutrition and Food Sciences}, volume = {2}, number = {2}, pages = {24-30}, doi = {10.11648/j.ijnfs.20130202.11}, url = {https://doi.org/10.11648/j.ijnfs.20130202.11}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20130202.11}, abstract = {The effect of high fat diet on lipid and carbohydrate metabolic changes was studied in mature male albino rats. The animals were rendered obese by feeding a high fat diet for 60 days. Half of obese rats were become diabetic by injecting with a reduced dose of alloxan; to produce a non insulin dependent diabetes mellitus state. These obese models of non diabetic and diabetic rats were compared with normal male rats kept on a basal diet for 60 days. The fat fed rats beside gaining weight showed a significant rise in their hepatic lipid contents and observed an insulin resistant state. Lipid profile of the omental adipose tissue exhibited a significantly higher total lipid content, but lower total cholesterol, triglycerides and phospholipids contents in both obese (non diabetic and diabetic) as compared with the normal rats. On the other hand, the brown adipose tissue showed a reduced fat catabolism with a significant rise in its phospholipid contents. Correlation between plasma atherogenic index and plasma fatty acids pattern showed that in the obese diabetic rats atherogenic index was positively correlated with total polyunsaturated fatty acids, while significantly negative correlation with total saturated fatty acids. This work showed that high fat substrates have been got remarkable impacts on rats body weight and metabolism.}, year = {2013} }
TY - JOUR T1 - Biochemical Changes in LIPID and Car-bohydrate Metabolism in Obese Diabetic Male Albino Rats AU - Mostafa M. Osfor AU - Osama Kensarah AU - Firas Azzeh AU - Mohammad A. Elmadbouly AU - Mona El-Qutry Y1 - 2013/03/10 PY - 2013 N1 - https://doi.org/10.11648/j.ijnfs.20130202.11 DO - 10.11648/j.ijnfs.20130202.11 T2 - International Journal of Nutrition and Food Sciences JF - International Journal of Nutrition and Food Sciences JO - International Journal of Nutrition and Food Sciences SP - 24 EP - 30 PB - Science Publishing Group SN - 2327-2716 UR - https://doi.org/10.11648/j.ijnfs.20130202.11 AB - The effect of high fat diet on lipid and carbohydrate metabolic changes was studied in mature male albino rats. The animals were rendered obese by feeding a high fat diet for 60 days. Half of obese rats were become diabetic by injecting with a reduced dose of alloxan; to produce a non insulin dependent diabetes mellitus state. These obese models of non diabetic and diabetic rats were compared with normal male rats kept on a basal diet for 60 days. The fat fed rats beside gaining weight showed a significant rise in their hepatic lipid contents and observed an insulin resistant state. Lipid profile of the omental adipose tissue exhibited a significantly higher total lipid content, but lower total cholesterol, triglycerides and phospholipids contents in both obese (non diabetic and diabetic) as compared with the normal rats. On the other hand, the brown adipose tissue showed a reduced fat catabolism with a significant rise in its phospholipid contents. Correlation between plasma atherogenic index and plasma fatty acids pattern showed that in the obese diabetic rats atherogenic index was positively correlated with total polyunsaturated fatty acids, while significantly negative correlation with total saturated fatty acids. This work showed that high fat substrates have been got remarkable impacts on rats body weight and metabolism. VL - 2 IS - 2 ER -