Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry

Niouma Nestor Leno; Foromo Guilavogui; Mohamed Diallo; Aboubacar Sidiki Magassouba; Youssouf Koita; Laye Kaba; Souleymane Chaloub; Andre Kamano; Alexandre Delamou; Alioune Camara

doi:doi:10.11648/j.ijidt.20230801.11

Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry

Niouma Nestor Leno, Foromo Guilavogui, Mohamed Diallo, Aboubacar Sidiki Magassouba, Youssouf Koita, Laye Kaba, Souleymane Chaloub, Andre Kamano, Alexandre Delamou, Alioune Camara

Published in International Journal of Infectious Diseases and Therapy (Volume 8, Issue 1)

Received: 20 December 2022 Accepted: 6 January 2023 Published: 17 January 2023

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Abstract

Introduction: The objective of this study was to estimate the prevalence of tuberculosis and to identify factors associated with its occurrence among HIV-infected patients on antiretroviral therapy. It also estimated the survival rate among HIV patients co-infected with TB and among HIV patients not co-infected with TB. Methods: In this study, two types of studies were used. An analytical cross-sectional study was used to estimate the prevalence of TB at the time of data collection or extraction among HIV-infected patients. A historical cohort study was used to analyze the survival of HIV patients on ART at different time points during their follow-up. We used Kaplan Meir survival analysis techniques to estimate the cumulative incidence of death among patients on antiretroviral therapy at different follow-up periods. We used multivariate logistic regression to identify associations significantly associated with the occurrence of TB in patients living with HIV. Results: The prevalence of tuberculosis among HIV-infected patients was 21.19%. The cumulative probability of death for patients on ART was 6.80%, or an incidence rate of 3.27 per 100 person-years. The advanced clinical stage of HIV infection at ART initiation, the low CD4 count at ART initiation, and the high viral load at ART initiation were statistically associated with the occurrence of TB in HIV-infected patients (all AOR > 1, p-value < 0.05). Conclusion: This study showed that the cumulative probability of death was higher in patients co-infected with HIV and TB than in those who were not. A mixed study (a prospective quantitative component and a qualitative component) could allow a better understanding of this phenomenon of tuberculosis occurrence among HIV-infected patients in Guinea.

Published in	International Journal of Infectious Diseases and Therapy (Volume 8, Issue 1)
DOI	10.11648/j.ijidt.20230801.11
Page(s)	1-9
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

HIV, Tuberculosis, Co-infection, Prevalence, Mortality, Guinea

References

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Niouma Nestor Leno, Foromo Guilavogui, Mohamed Diallo, Aboubacar Sidiki Magassouba, Youssouf Koita, et al. (2023). Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry. International Journal of Infectious Diseases and Therapy, 8(1), 1-9. https://doi.org/10.11648/j.ijidt.20230801.11

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Niouma Nestor Leno; Foromo Guilavogui; Mohamed Diallo; Aboubacar Sidiki Magassouba; Youssouf Koita, et al. Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry. Int. J. Infect. Dis. Ther. 2023, 8(1), 1-9. doi: 10.11648/j.ijidt.20230801.11

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AMA Style

Niouma Nestor Leno, Foromo Guilavogui, Mohamed Diallo, Aboubacar Sidiki Magassouba, Youssouf Koita, et al. Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry. Int J Infect Dis Ther. 2023;8(1):1-9. doi: 10.11648/j.ijidt.20230801.11

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@article{10.11648/j.ijidt.20230801.11,
  author = {Niouma Nestor Leno and Foromo Guilavogui and Mohamed Diallo and Aboubacar Sidiki Magassouba and Youssouf Koita and Laye Kaba and Souleymane Chaloub and Andre Kamano and Alexandre Delamou and Alioune Camara},
  title = {Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {8},
  number = {1},
  pages = {1-9},
  doi = {10.11648/j.ijidt.20230801.11},
  url = {https://doi.org/10.11648/j.ijidt.20230801.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20230801.11},
  abstract = {Introduction: The objective of this study was to estimate the prevalence of tuberculosis and to identify factors associated with its occurrence among HIV-infected patients on antiretroviral therapy. It also estimated the survival rate among HIV patients co-infected with TB and among HIV patients not co-infected with TB. Methods: In this study, two types of studies were used. An analytical cross-sectional study was used to estimate the prevalence of TB at the time of data collection or extraction among HIV-infected patients. A historical cohort study was used to analyze the survival of HIV patients on ART at different time points during their follow-up. We used Kaplan Meir survival analysis techniques to estimate the cumulative incidence of death among patients on antiretroviral therapy at different follow-up periods. We used multivariate logistic regression to identify associations significantly associated with the occurrence of TB in patients living with HIV. Results: The prevalence of tuberculosis among HIV-infected patients was 21.19%. The cumulative probability of death for patients on ART was 6.80%, or an incidence rate of 3.27 per 100 person-years. The advanced clinical stage of HIV infection at ART initiation, the low CD4 count at ART initiation, and the high viral load at ART initiation were statistically associated with the occurrence of TB in HIV-infected patients (all AOR > 1, p-value Conclusion: This study showed that the cumulative probability of death was higher in patients co-infected with HIV and TB than in those who were not. A mixed study (a prospective quantitative component and a qualitative component) could allow a better understanding of this phenomenon of tuberculosis occurrence among HIV-infected patients in Guinea.},
 year = {2023}
}

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TY  - JOUR
T1  - Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry
AU  - Niouma Nestor Leno
AU  - Foromo Guilavogui
AU  - Mohamed Diallo
AU  - Aboubacar Sidiki Magassouba
AU  - Youssouf Koita
AU  - Laye Kaba
AU  - Souleymane Chaloub
AU  - Andre Kamano
AU  - Alexandre Delamou
AU  - Alioune Camara
Y1  - 2023/01/17
PY  - 2023
N1  - https://doi.org/10.11648/j.ijidt.20230801.11
DO  - 10.11648/j.ijidt.20230801.11
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 1
EP  - 9
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20230801.11
AB  - Introduction: The objective of this study was to estimate the prevalence of tuberculosis and to identify factors associated with its occurrence among HIV-infected patients on antiretroviral therapy. It also estimated the survival rate among HIV patients co-infected with TB and among HIV patients not co-infected with TB. Methods: In this study, two types of studies were used. An analytical cross-sectional study was used to estimate the prevalence of TB at the time of data collection or extraction among HIV-infected patients. A historical cohort study was used to analyze the survival of HIV patients on ART at different time points during their follow-up. We used Kaplan Meir survival analysis techniques to estimate the cumulative incidence of death among patients on antiretroviral therapy at different follow-up periods. We used multivariate logistic regression to identify associations significantly associated with the occurrence of TB in patients living with HIV. Results: The prevalence of tuberculosis among HIV-infected patients was 21.19%. The cumulative probability of death for patients on ART was 6.80%, or an incidence rate of 3.27 per 100 person-years. The advanced clinical stage of HIV infection at ART initiation, the low CD4 count at ART initiation, and the high viral load at ART initiation were statistically associated with the occurrence of TB in HIV-infected patients (all AOR > 1, p-value Conclusion: This study showed that the cumulative probability of death was higher in patients co-infected with HIV and TB than in those who were not. A mixed study (a prospective quantitative component and a qualitative component) could allow a better understanding of this phenomenon of tuberculosis occurrence among HIV-infected patients in Guinea.
VL  - 8
IS  - 1
ER  -

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Author Information

Niouma Nestor Leno

Department of Public Health, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
Foromo Guilavogui

African Center of Excellence for Prevention and Control of Communicable Diseases (CEA-PCMT), Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
Mohamed Diallo

National AIDS and Hepatitis Control Program, Conakry, Guinea
Aboubacar Sidiki Magassouba

Department of Public Health, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
Youssouf Koita

National AIDS and Hepatitis Control Program, Conakry, Guinea
Laye Kaba

National AIDS and Hepatitis Control Program, Conakry, Guinea
Souleymane Chaloub

NGO Doctors Without Borders of Belgium, Conakry, Guinea
Andre Kamano

NGO Doctors Without Borders of Belgium, Conakry, Guinea
Alexandre Delamou

Department of Public Health, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
Alioune Camara

Department of Public Health, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea

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APA Style

Niouma Nestor Leno, Foromo Guilavogui, Mohamed Diallo, Aboubacar Sidiki Magassouba, Youssouf Koita, et al. (2023). Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry. International Journal of Infectious Diseases and Therapy, 8(1), 1-9. https://doi.org/10.11648/j.ijidt.20230801.11

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ACS Style

Niouma Nestor Leno; Foromo Guilavogui; Mohamed Diallo; Aboubacar Sidiki Magassouba; Youssouf Koita, et al. Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry. Int. J. Infect. Dis. Ther. 2023, 8(1), 1-9. doi: 10.11648/j.ijidt.20230801.11

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AMA Style

Niouma Nestor Leno, Foromo Guilavogui, Mohamed Diallo, Aboubacar Sidiki Magassouba, Youssouf Koita, et al. Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry. Int J Infect Dis Ther. 2023;8(1):1-9. doi: 10.11648/j.ijidt.20230801.11

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@article{10.11648/j.ijidt.20230801.11,
  author = {Niouma Nestor Leno and Foromo Guilavogui and Mohamed Diallo and Aboubacar Sidiki Magassouba and Youssouf Koita and Laye Kaba and Souleymane Chaloub and Andre Kamano and Alexandre Delamou and Alioune Camara},
  title = {Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {8},
  number = {1},
  pages = {1-9},
  doi = {10.11648/j.ijidt.20230801.11},
  url = {https://doi.org/10.11648/j.ijidt.20230801.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20230801.11},
  abstract = {Introduction: The objective of this study was to estimate the prevalence of tuberculosis and to identify factors associated with its occurrence among HIV-infected patients on antiretroviral therapy. It also estimated the survival rate among HIV patients co-infected with TB and among HIV patients not co-infected with TB. Methods: In this study, two types of studies were used. An analytical cross-sectional study was used to estimate the prevalence of TB at the time of data collection or extraction among HIV-infected patients. A historical cohort study was used to analyze the survival of HIV patients on ART at different time points during their follow-up. We used Kaplan Meir survival analysis techniques to estimate the cumulative incidence of death among patients on antiretroviral therapy at different follow-up periods. We used multivariate logistic regression to identify associations significantly associated with the occurrence of TB in patients living with HIV. Results: The prevalence of tuberculosis among HIV-infected patients was 21.19%. The cumulative probability of death for patients on ART was 6.80%, or an incidence rate of 3.27 per 100 person-years. The advanced clinical stage of HIV infection at ART initiation, the low CD4 count at ART initiation, and the high viral load at ART initiation were statistically associated with the occurrence of TB in HIV-infected patients (all AOR > 1, p-value Conclusion: This study showed that the cumulative probability of death was higher in patients co-infected with HIV and TB than in those who were not. A mixed study (a prospective quantitative component and a qualitative component) could allow a better understanding of this phenomenon of tuberculosis occurrence among HIV-infected patients in Guinea.},
 year = {2023}
}

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TY  - JOUR
T1  - Prevalence and Mortality Associated with Tuberculosis Among HIV-Infected Patients in High-Volume HIV Care Sites in Conakry
AU  - Niouma Nestor Leno
AU  - Foromo Guilavogui
AU  - Mohamed Diallo
AU  - Aboubacar Sidiki Magassouba
AU  - Youssouf Koita
AU  - Laye Kaba
AU  - Souleymane Chaloub
AU  - Andre Kamano
AU  - Alexandre Delamou
AU  - Alioune Camara
Y1  - 2023/01/17
PY  - 2023
N1  - https://doi.org/10.11648/j.ijidt.20230801.11
DO  - 10.11648/j.ijidt.20230801.11
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 1
EP  - 9
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20230801.11
AB  - Introduction: The objective of this study was to estimate the prevalence of tuberculosis and to identify factors associated with its occurrence among HIV-infected patients on antiretroviral therapy. It also estimated the survival rate among HIV patients co-infected with TB and among HIV patients not co-infected with TB. Methods: In this study, two types of studies were used. An analytical cross-sectional study was used to estimate the prevalence of TB at the time of data collection or extraction among HIV-infected patients. A historical cohort study was used to analyze the survival of HIV patients on ART at different time points during their follow-up. We used Kaplan Meir survival analysis techniques to estimate the cumulative incidence of death among patients on antiretroviral therapy at different follow-up periods. We used multivariate logistic regression to identify associations significantly associated with the occurrence of TB in patients living with HIV. Results: The prevalence of tuberculosis among HIV-infected patients was 21.19%. The cumulative probability of death for patients on ART was 6.80%, or an incidence rate of 3.27 per 100 person-years. The advanced clinical stage of HIV infection at ART initiation, the low CD4 count at ART initiation, and the high viral load at ART initiation were statistically associated with the occurrence of TB in HIV-infected patients (all AOR > 1, p-value Conclusion: This study showed that the cumulative probability of death was higher in patients co-infected with HIV and TB than in those who were not. A mixed study (a prospective quantitative component and a qualitative component) could allow a better understanding of this phenomenon of tuberculosis occurrence among HIV-infected patients in Guinea.
VL  - 8
IS  - 1
ER  -

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