Based on matrine (Mat), chitosan (CS) and carboxymethyl chitosan (CMC) as a plant source drug and a carrier material. A novel Mat/CS drug-loading film and Mat/CS/CMC drug-loading film were prepared. The mechanical properties, surface morphology and drug-loading capacity of the drug-loading film were characterized in vitro. The results showed that the mechanical strength had maximum value and the tensile modulus was up to 0.79 MPa when the molecular weight of CS was 650,000 and the mass ratio of CS/glycerol was 1:1.4. The aggregate distribution of the Mat was located in the bottom surface of the film and was asymmetrical by SEM observation. Via release behavior tests in vitro, the drug-loading film showed high drug-loading capacity and long slowing-release properties. The release time of the drug-loading film increased along with the increase of CS molecular weight. When the bottom of the drug-loading film was coated with a layer of 1% carboxymethyl chitosan, the release times of the drug-loading film was increased to 108 h. Thus, we conclude that the matrix materials of the drug-loading film are natural, green, nontoxic and biodegradable, and the preparation method is simple and avoid using a large number of organic solvents. The novel drug-loading film can obviously prolong release of drugs.
| Published in | International Journal of Biomedical Materials Research (Volume 6, Issue 1) |
| DOI | 10.11648/j.ijbmr.20180601.14 |
| Page(s) | 20-25 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Chitosan, Matrine, Drug-Loading Film, Release Behavior
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APA Style
Chunlei Zhang, Jinghua Li. (2018). Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro. International Journal of Biomedical Materials Research, 6(1), 20-25. https://doi.org/10.11648/j.ijbmr.20180601.14
ACS Style
Chunlei Zhang; Jinghua Li. Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro. Int. J. Biomed. Mater. Res. 2018, 6(1), 20-25. doi: 10.11648/j.ijbmr.20180601.14
AMA Style
Chunlei Zhang, Jinghua Li. Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro. Int J Biomed Mater Res. 2018;6(1):20-25. doi: 10.11648/j.ijbmr.20180601.14
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Download@article{10.11648/j.ijbmr.20180601.14,
author = {Chunlei Zhang and Jinghua Li},
title = {Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro},
journal = {International Journal of Biomedical Materials Research},
volume = {6},
number = {1},
pages = {20-25},
doi = {10.11648/j.ijbmr.20180601.14},
url = {https://doi.org/10.11648/j.ijbmr.20180601.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20180601.14},
abstract = {Based on matrine (Mat), chitosan (CS) and carboxymethyl chitosan (CMC) as a plant source drug and a carrier material. A novel Mat/CS drug-loading film and Mat/CS/CMC drug-loading film were prepared. The mechanical properties, surface morphology and drug-loading capacity of the drug-loading film were characterized in vitro. The results showed that the mechanical strength had maximum value and the tensile modulus was up to 0.79 MPa when the molecular weight of CS was 650,000 and the mass ratio of CS/glycerol was 1:1.4. The aggregate distribution of the Mat was located in the bottom surface of the film and was asymmetrical by SEM observation. Via release behavior tests in vitro, the drug-loading film showed high drug-loading capacity and long slowing-release properties. The release time of the drug-loading film increased along with the increase of CS molecular weight. When the bottom of the drug-loading film was coated with a layer of 1% carboxymethyl chitosan, the release times of the drug-loading film was increased to 108 h. Thus, we conclude that the matrix materials of the drug-loading film are natural, green, nontoxic and biodegradable, and the preparation method is simple and avoid using a large number of organic solvents. The novel drug-loading film can obviously prolong release of drugs.},
year = {2018}
}
TY - JOUR T1 - Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro AU - Chunlei Zhang AU - Jinghua Li Y1 - 2018/05/08 PY - 2018 N1 - https://doi.org/10.11648/j.ijbmr.20180601.14 DO - 10.11648/j.ijbmr.20180601.14 T2 - International Journal of Biomedical Materials Research JF - International Journal of Biomedical Materials Research JO - International Journal of Biomedical Materials Research SP - 20 EP - 25 PB - Science Publishing Group SN - 2330-7579 UR - https://doi.org/10.11648/j.ijbmr.20180601.14 AB - Based on matrine (Mat), chitosan (CS) and carboxymethyl chitosan (CMC) as a plant source drug and a carrier material. A novel Mat/CS drug-loading film and Mat/CS/CMC drug-loading film were prepared. The mechanical properties, surface morphology and drug-loading capacity of the drug-loading film were characterized in vitro. The results showed that the mechanical strength had maximum value and the tensile modulus was up to 0.79 MPa when the molecular weight of CS was 650,000 and the mass ratio of CS/glycerol was 1:1.4. The aggregate distribution of the Mat was located in the bottom surface of the film and was asymmetrical by SEM observation. Via release behavior tests in vitro, the drug-loading film showed high drug-loading capacity and long slowing-release properties. The release time of the drug-loading film increased along with the increase of CS molecular weight. When the bottom of the drug-loading film was coated with a layer of 1% carboxymethyl chitosan, the release times of the drug-loading film was increased to 108 h. Thus, we conclude that the matrix materials of the drug-loading film are natural, green, nontoxic and biodegradable, and the preparation method is simple and avoid using a large number of organic solvents. The novel drug-loading film can obviously prolong release of drugs. VL - 6 IS - 1 ER -
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