Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats

Z. Deniz Sahın Inan; Serpil Unver Saraydın

doi:doi:10.11648/j.ijbmr.20130101.11

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Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats

Z. Deniz Sahın Inan, Serpil Unver Saraydın

Published in International Journal of Biomedical Materials Research (Volume 1, Issue 1)

Received: 17 April 2013 Published: 20 May 2013

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Abstract

Chitosan is a naturally occurring substance that stimulates correct deposition, assembly and orientation of collagen fibres in extracellular matrix components in wounds and promotes migration of inflammatory cells. Fibroblast growth factor (FGF) is one of the most important growth factors playing crucial roles in angiogenesis and wound healing. Biologically, it acts via binding to the cellular surface receptors. FGFR3 is one of the most important receptors. Therefore the aim of the present study was to investigate, histologically and histochemically, the effect of chitosan on wound healing in experimentally diabetic rats divided into four groups. When compared to the diabetic and the control groups, chitosan group had more inflammatory cells, endothelial cells, newly formed blood vessels and reticular – collagen fibres in the wound healing area from the third day of operation.Moreover, in Chitosan Group, stronger VEGF and FGFR3 immunolo-calizations were evident and all steps of wound healing process were more regular. FGFR3 antibody used in this study had been tested only on diabetic wound healing. In conclusion, we have concluded that application of chitosan was essential to accelarate wound healing process in diabetic patients

Published in	International Journal of Biomedical Materials Research (Volume 1, Issue 1)
DOI	10.11648/j.ijbmr.20130101.11
Page(s)	1-8
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Diabetes, Wound Healing, Chitosan, VEGF, FGFR3

References

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APA Style

Z. Deniz Sahın Inan, Serpil Unver Saraydın. (2013). Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats. International Journal of Biomedical Materials Research, 1(1), 1-8. https://doi.org/10.11648/j.ijbmr.20130101.11

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ACS Style

Z. Deniz Sahın Inan; Serpil Unver Saraydın. Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats. Int. J. Biomed. Mater. Res. 2013, 1(1), 1-8. doi: 10.11648/j.ijbmr.20130101.11

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AMA Style

Z. Deniz Sahın Inan, Serpil Unver Saraydın. Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats. Int J Biomed Mater Res. 2013;1(1):1-8. doi: 10.11648/j.ijbmr.20130101.11

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@article{10.11648/j.ijbmr.20130101.11,
  author = {Z. Deniz Sahın Inan and Serpil Unver Saraydın},
  title = {Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats},
  journal = {International Journal of Biomedical Materials Research},
  volume = {1},
  number = {1},
  pages = {1-8},
  doi = {10.11648/j.ijbmr.20130101.11},
  url = {https://doi.org/10.11648/j.ijbmr.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20130101.11},
  abstract = {Chitosan is a naturally occurring substance that stimulates correct deposition, assembly and orientation of collagen fibres in extracellular matrix components in wounds and promotes migration of inflammatory cells. Fibroblast growth factor (FGF) is one of the most important growth factors playing crucial roles in angiogenesis and wound healing. Biologically, it acts via binding to the cellular surface receptors. FGFR3 is one of the most important receptors. Therefore the aim of the present study was to investigate, histologically and histochemically, the effect of chitosan on wound healing in experimentally diabetic rats divided into four groups. When compared to the diabetic and the control groups, chitosan group had more inflammatory cells, endothelial cells, newly formed blood vessels and reticular – collagen fibres in the wound healing area from the third day of operation.Moreover, in Chitosan Group, stronger VEGF and FGFR3 immunolo-calizations were evident and all steps of wound healing process were more regular. FGFR3 antibody used in this study had been tested only on diabetic wound healing. In conclusion, we have concluded that application of chitosan was essential to accelarate wound healing process in diabetic patients},
 year = {2013}
}

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TY  - JOUR
T1  - Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats
AU  - Z. Deniz Sahın Inan
AU  - Serpil Unver Saraydın
Y1  - 2013/05/20
PY  - 2013
N1  - https://doi.org/10.11648/j.ijbmr.20130101.11
DO  - 10.11648/j.ijbmr.20130101.11
T2  - International Journal of Biomedical Materials Research
JF  - International Journal of Biomedical Materials Research
JO  - International Journal of Biomedical Materials Research
SP  - 1
EP  - 8
PB  - Science Publishing Group
SN  - 2330-7579
UR  - https://doi.org/10.11648/j.ijbmr.20130101.11
AB  - Chitosan is a naturally occurring substance that stimulates correct deposition, assembly and orientation of collagen fibres in extracellular matrix components in wounds and promotes migration of inflammatory cells. Fibroblast growth factor (FGF) is one of the most important growth factors playing crucial roles in angiogenesis and wound healing. Biologically, it acts via binding to the cellular surface receptors. FGFR3 is one of the most important receptors. Therefore the aim of the present study was to investigate, histologically and histochemically, the effect of chitosan on wound healing in experimentally diabetic rats divided into four groups. When compared to the diabetic and the control groups, chitosan group had more inflammatory cells, endothelial cells, newly formed blood vessels and reticular – collagen fibres in the wound healing area from the third day of operation.Moreover, in Chitosan Group, stronger VEGF and FGFR3 immunolo-calizations were evident and all steps of wound healing process were more regular. FGFR3 antibody used in this study had been tested only on diabetic wound healing. In conclusion, we have concluded that application of chitosan was essential to accelarate wound healing process in diabetic patients
VL  - 1
IS  - 1
ER  -

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Z. Deniz Sahın Inan
Serpil Unver Saraydın

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APA Style

Z. Deniz Sahın Inan, Serpil Unver Saraydın. (2013). Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats. International Journal of Biomedical Materials Research, 1(1), 1-8. https://doi.org/10.11648/j.ijbmr.20130101.11

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ACS Style

Z. Deniz Sahın Inan; Serpil Unver Saraydın. Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats. Int. J. Biomed. Mater. Res. 2013, 1(1), 1-8. doi: 10.11648/j.ijbmr.20130101.11

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AMA Style

Z. Deniz Sahın Inan, Serpil Unver Saraydın. Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats. Int J Biomed Mater Res. 2013;1(1):1-8. doi: 10.11648/j.ijbmr.20130101.11

Copy | Download

@article{10.11648/j.ijbmr.20130101.11,
  author = {Z. Deniz Sahın Inan and Serpil Unver Saraydın},
  title = {Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats},
  journal = {International Journal of Biomedical Materials Research},
  volume = {1},
  number = {1},
  pages = {1-8},
  doi = {10.11648/j.ijbmr.20130101.11},
  url = {https://doi.org/10.11648/j.ijbmr.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20130101.11},
  abstract = {Chitosan is a naturally occurring substance that stimulates correct deposition, assembly and orientation of collagen fibres in extracellular matrix components in wounds and promotes migration of inflammatory cells. Fibroblast growth factor (FGF) is one of the most important growth factors playing crucial roles in angiogenesis and wound healing. Biologically, it acts via binding to the cellular surface receptors. FGFR3 is one of the most important receptors. Therefore the aim of the present study was to investigate, histologically and histochemically, the effect of chitosan on wound healing in experimentally diabetic rats divided into four groups. When compared to the diabetic and the control groups, chitosan group had more inflammatory cells, endothelial cells, newly formed blood vessels and reticular – collagen fibres in the wound healing area from the third day of operation.Moreover, in Chitosan Group, stronger VEGF and FGFR3 immunolo-calizations were evident and all steps of wound healing process were more regular. FGFR3 antibody used in this study had been tested only on diabetic wound healing. In conclusion, we have concluded that application of chitosan was essential to accelarate wound healing process in diabetic patients},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats
AU  - Z. Deniz Sahın Inan
AU  - Serpil Unver Saraydın
Y1  - 2013/05/20
PY  - 2013
N1  - https://doi.org/10.11648/j.ijbmr.20130101.11
DO  - 10.11648/j.ijbmr.20130101.11
T2  - International Journal of Biomedical Materials Research
JF  - International Journal of Biomedical Materials Research
JO  - International Journal of Biomedical Materials Research
SP  - 1
EP  - 8
PB  - Science Publishing Group
SN  - 2330-7579
UR  - https://doi.org/10.11648/j.ijbmr.20130101.11
AB  - Chitosan is a naturally occurring substance that stimulates correct deposition, assembly and orientation of collagen fibres in extracellular matrix components in wounds and promotes migration of inflammatory cells. Fibroblast growth factor (FGF) is one of the most important growth factors playing crucial roles in angiogenesis and wound healing. Biologically, it acts via binding to the cellular surface receptors. FGFR3 is one of the most important receptors. Therefore the aim of the present study was to investigate, histologically and histochemically, the effect of chitosan on wound healing in experimentally diabetic rats divided into four groups. When compared to the diabetic and the control groups, chitosan group had more inflammatory cells, endothelial cells, newly formed blood vessels and reticular – collagen fibres in the wound healing area from the third day of operation.Moreover, in Chitosan Group, stronger VEGF and FGFR3 immunolo-calizations were evident and all steps of wound healing process were more regular. FGFR3 antibody used in this study had been tested only on diabetic wound healing. In conclusion, we have concluded that application of chitosan was essential to accelarate wound healing process in diabetic patients
VL  - 1
IS  - 1
ER  -

Copy | Download