Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa

Gueth Kundabi; Gibency Mfulani; Karim Assani; Nina Domo; Aleine Budiongo; Jonathan Kukila; Eric Mukenge; John Senga; Bodi Mabiala; René Ngiyulu; Jean-Lambert Gini

doi:doi:10.11648/j.ejcbs.20230903.11

Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa

Gueth Kundabi, Gibency Mfulani, Karim Assani, Nina Domo, Aleine Budiongo, Jonathan Kukila, Eric Mukenge, John Senga, Bodi Mabiala, René Ngiyulu, Jean-Lambert Gini

Published in European Journal of Clinical and Biomedical Sciences (Volume 9, Issue 3)

Received: 11 June 2023 Accepted: 11 July 2023 Published: 31 August 2023

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Background: Hemophilia is a congenital, inherited bleeding disorder that prevents blood from clotting, causing abnormally long bleeding. It remains underdiagnosed in Africa and particularly in the Democratic Republic of Congo, where it remains poorly known to the population and health professionals. The present study aims to determine the clinical profile and cardiovascular risk factors in hemophiliacs at the University Clinics of Kinshasa. Methods: This is a cross-sectional study with an analytical aim, in which 155 patients (children and adults) with a haemorrhagic syndrome were included. The diagnosis of haemophilia was confirmed in thirty-six patients, all male; 22 hemophiliac patients regularly followed were matched with 24 non-hemophilic patients (control group). Results: hemophilia A represented 81% and hemophilia B 19%. The most represented age group was between 3 to 6 years (19%). Regarding the severity of the disease, half of the patients, or 50%, presented with severe hemophilia, the main symptom being hemarthrosis (30%). Of our total sample of hemophiliacs, we had recorded two cases of death (5.5%). Regarding cardiovascular risk factors, only the deterioration of myocardial function was found in one patient (4.5%). Conclusion: hemophilia is a disabling disease, which alters the quality of life of patients. Cardiovascular risk factors seem to be lower in Congolese hemophiliacs, however, ultrasound monitoring is necessary in order to prevent any pejorative evolution.

Published in	European Journal of Clinical and Biomedical Sciences (Volume 9, Issue 3)
DOI	10.11648/j.ejcbs.20230903.11
Page(s)	28-37
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hemophilia, Cardiovascular Risk Factors, Clinical Profile, University Clinics of Kinshasa

References

[1]	Schved JF. Hemophilia: physiopathology and molecular bases. Medico-surgical encyclopedia. Ed. Elsevier Masson SAS, Paris 2008: Hematology, 13-021-B10: p 1–14.
[2]	Annual global survey and word bleesing disorders registry haemophilia 2020: http://shiny.wfh.org/ags/
[3]	Alperstein W, Corrales F, Tamariz L, Palacio G and Davis J. Prevalence of Hypertension (HTN) and cardiovascular risk factors in a hospitalized paediatric Haemophilia population, J Pediatr Hematol. Oncol. 40 (2018) 196–199.
[4]	Franchini M and Mannucci PM. Co-morbidities and quality of life in elderly persons with haemophilia. Br J Haematol 2010; 148: 522-33.
[5]	Fransen van de Putte DE, Fischer K and Pulles AE. Non-fatal cardiovascular disease, malignancies, and other co-morbidity in adult haemophilia patients. Thromb Res 2012; 130: 157–62.
[6]	Zeynep C, Pelin K, and Birsen U. Myocardial functions, blood pressure changes, and arterial stiffness in children with severe haemophilia A. Original article journal homepage: www.elsevier.com/locate/thromresl.
[7]	Pocoski J., A. Ma, CM Kessler, S. Boklage and TJ Humphries. Cardiovascular comorbidities are increased in US patients with haemophilia A: a retrospective database analysis, Haemophilia 20 (2014) 472–478, https://doi.org/10.1111/hae. 12339.
[8]	Ragni MV and Moore CG. Atherosclerotic heart disease: prevalence and risk factors in hospitalized men with haemophilia A. Haemophilia 2011; 17: 867–71.
[9]	Limjoco J, CD Thornburg, Risk factors for cardiovascular disease in children and young adults with haemophilia, Haemophilia 24 (2018) 747–754, https://doi.org/10.1111/hae.13585.
[10]	Mannucci PM and Mauser-Bunschoten EP. Cardiovascular disease in haemophilia patients: a contemporary issue. Haemophilia 2010; 16 Suppl 3: 58–66.
[11]	Maria R. Hemophilia in Morocco. Current status and prospects. Thesis for obtaining the doctorate in Medicine 2012; pg 2–44.
[12]	Madouni S and Madani K. Management of hemophilia, Memory of the internship, faculty of Medicine, Abou Beckr University of Algeria, 2013; pg 8–12.
[13]	World bleeding disorders registry 2019 data report: http://wbdr.wfh.org/ags/
[14]	Schved JF. Hemophilia treatments. Medical and Surgical Encyclopedia. Ed. Elsevier Masson SAS, Paris 2008: Hematology, 13-021-B20: p 1–11.
[15]	Chambost A and Meunier S. Challenges of early pediatric management of severe hemophilia. Archives of Pediatrics. 2006; 13: 1423-30.
[16]	Sharathkumar A, Soucie J, Trawinski B, Greist A, Shapiro A et al. Prevalence and risk factors of cardiovascular disease (CVD) events among patients with haemophilia: experience of a single haemophilia treatment center in the United States (US). Haemophilia 2011; 17: 597–604.
[17]	Rosendaal FR, Smit C, Varekamp I, Bröcker-Vriends AH, Van Dijck H, Suurmeijer TP, et al. Modern haemophilia treatment: medical improvements and quality of life. J Intern Med 1990; 228: 633-640.
[18]	Kulkarni R, Soucie JM and Evatt BL, Hemophilia Surveillance System Project Investigators. Prevalence and risk factors for heart illness among males with haemophilia. Am J Hematol 2005; 79: 36–42.
[19]	Wong M, Macgregor D, Stuckless S, Barrett B, Kawaja M and Scully MF. Health-related quality of life in a cohort of adult patients with mild hemophilia A. J Thromb Haemost 2008; 6: 755–761.
[20]	Yidiz R, Miesbach W, Alesci S, Krekeler S, and Seifried E. Comorbidities and bleeding pattern in elderly haemophilia A patients. Haemophilia 2009; 15: 894–9.
[21]	Staritz P, de Moerloose P, Schutgens R and Dolan G. Applicability of the European Society of Cardiology guidelines on management of acute coronary syndromes to people with haemophilia- an assessment by the ADVANCE Working Group. Haemophilia 2013; 833–40.

Cite This Article

Plain Text BibTeX RIS

APA Style

Gueth Kundabi, Gibency Mfulani, Karim Assani, Nina Domo, Aleine Budiongo, et al. (2023). Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa. European Journal of Clinical and Biomedical Sciences, 9(3), 28-37. https://doi.org/10.11648/j.ejcbs.20230903.11

Copy | Download

ACS Style

Gueth Kundabi; Gibency Mfulani; Karim Assani; Nina Domo; Aleine Budiongo, et al. Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa. Eur. J. Clin. Biomed. Sci. 2023, 9(3), 28-37. doi: 10.11648/j.ejcbs.20230903.11

Copy | Download

AMA Style

Gueth Kundabi, Gibency Mfulani, Karim Assani, Nina Domo, Aleine Budiongo, et al. Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa. Eur J Clin Biomed Sci. 2023;9(3):28-37. doi: 10.11648/j.ejcbs.20230903.11

Copy | Download

@article{10.11648/j.ejcbs.20230903.11,
  author = {Gueth Kundabi and Gibency Mfulani and Karim Assani and Nina Domo and Aleine Budiongo and Jonathan Kukila and Eric Mukenge and John Senga and Bodi Mabiala and René Ngiyulu and Jean-Lambert Gini},
  title = {Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa},
  journal = {European Journal of Clinical and Biomedical Sciences},
  volume = {9},
  number = {3},
  pages = {28-37},
  doi = {10.11648/j.ejcbs.20230903.11},
  url = {https://doi.org/10.11648/j.ejcbs.20230903.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20230903.11},
  abstract = {Background: Hemophilia is a congenital, inherited bleeding disorder that prevents blood from clotting, causing abnormally long bleeding. It remains underdiagnosed in Africa and particularly in the Democratic Republic of Congo, where it remains poorly known to the population and health professionals. The present study aims to determine the clinical profile and cardiovascular risk factors in hemophiliacs at the University Clinics of Kinshasa. Methods: This is a cross-sectional study with an analytical aim, in which 155 patients (children and adults) with a haemorrhagic syndrome were included. The diagnosis of haemophilia was confirmed in thirty-six patients, all male; 22 hemophiliac patients regularly followed were matched with 24 non-hemophilic patients (control group). Results: hemophilia A represented 81% and hemophilia B 19%. The most represented age group was between 3 to 6 years (19%). Regarding the severity of the disease, half of the patients, or 50%, presented with severe hemophilia, the main symptom being hemarthrosis (30%). Of our total sample of hemophiliacs, we had recorded two cases of death (5.5%). Regarding cardiovascular risk factors, only the deterioration of myocardial function was found in one patient (4.5%). Conclusion: hemophilia is a disabling disease, which alters the quality of life of patients. Cardiovascular risk factors seem to be lower in Congolese hemophiliacs, however, ultrasound monitoring is necessary in order to prevent any pejorative evolution.},
 year = {2023}
}

Copy | Download

TY - JOUR
T1 - Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa
AU - Gueth Kundabi
AU - Gibency Mfulani
AU - Karim Assani
AU - Nina Domo
AU - Aleine Budiongo
AU - Jonathan Kukila
AU - Eric Mukenge
AU - John Senga
AU - Bodi Mabiala
AU - René Ngiyulu
AU - Jean-Lambert Gini
Y1 - 2023/08/31
PY - 2023
N1 - https://doi.org/10.11648/j.ejcbs.20230903.11
DO - 10.11648/j.ejcbs.20230903.11
T2 - European Journal of Clinical and Biomedical Sciences
JF - European Journal of Clinical and Biomedical Sciences
JO - European Journal of Clinical and Biomedical Sciences
SP - 28
EP - 37
PB - Science Publishing Group
SN - 2575-5005
UR - https://doi.org/10.11648/j.ejcbs.20230903.11
AB - Background: Hemophilia is a congenital, inherited bleeding disorder that prevents blood from clotting, causing abnormally long bleeding. It remains underdiagnosed in Africa and particularly in the Democratic Republic of Congo, where it remains poorly known to the population and health professionals. The present study aims to determine the clinical profile and cardiovascular risk factors in hemophiliacs at the University Clinics of Kinshasa. Methods: This is a cross-sectional study with an analytical aim, in which 155 patients (children and adults) with a haemorrhagic syndrome were included. The diagnosis of haemophilia was confirmed in thirty-six patients, all male; 22 hemophiliac patients regularly followed were matched with 24 non-hemophilic patients (control group). Results: hemophilia A represented 81% and hemophilia B 19%. The most represented age group was between 3 to 6 years (19%). Regarding the severity of the disease, half of the patients, or 50%, presented with severe hemophilia, the main symptom being hemarthrosis (30%). Of our total sample of hemophiliacs, we had recorded two cases of death (5.5%). Regarding cardiovascular risk factors, only the deterioration of myocardial function was found in one patient (4.5%). Conclusion: hemophilia is a disabling disease, which alters the quality of life of patients. Cardiovascular risk factors seem to be lower in Congolese hemophiliacs, however, ultrasound monitoring is necessary in order to prevent any pejorative evolution.
VL - 9
IS - 3
ER -

Copy | Download

Author Information

Gueth Kundabi

Hematology-Oncology Service, Department of Pediatrics, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo
Gibency Mfulani

Department of Anesthesia-Resuscitation, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo
Karim Assani

Hematology-Oncology Service, Department of Pediatrics, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo
Nina Domo

Hematology-Oncology Service, Department of Pediatrics, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo
Aleine Budiongo

Hematology-Oncology Service, Department of Pediatrics, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo
Jonathan Kukila

Department of Hematology, Department of Medical Biology, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo
Eric Mukenge

Department of Hematology, Department of Medical Biology, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo
John Senga

Cardiology Service, Department of Paediatrics, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo
Bodi Mabiala

Emergency Department, Department of Paediatrics, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo
René Ngiyulu

Hematology-Oncology Service, Department of Pediatrics, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo
Jean-Lambert Gini

Hematology-Oncology Service, Department of Pediatrics, Kinshasa University Clinics, Faculty of Medecine, University of Kinshasa, Kinshasa, DR Congo

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Gueth Kundabi, Gibency Mfulani, Karim Assani, Nina Domo, Aleine Budiongo, et al. (2023). Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa. European Journal of Clinical and Biomedical Sciences, 9(3), 28-37. https://doi.org/10.11648/j.ejcbs.20230903.11

Copy | Download

ACS Style

Gueth Kundabi; Gibency Mfulani; Karim Assani; Nina Domo; Aleine Budiongo, et al. Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa. Eur. J. Clin. Biomed. Sci. 2023, 9(3), 28-37. doi: 10.11648/j.ejcbs.20230903.11

Copy | Download

AMA Style

Gueth Kundabi, Gibency Mfulani, Karim Assani, Nina Domo, Aleine Budiongo, et al. Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa. Eur J Clin Biomed Sci. 2023;9(3):28-37. doi: 10.11648/j.ejcbs.20230903.11

Copy | Download

@article{10.11648/j.ejcbs.20230903.11,
  author = {Gueth Kundabi and Gibency Mfulani and Karim Assani and Nina Domo and Aleine Budiongo and Jonathan Kukila and Eric Mukenge and John Senga and Bodi Mabiala and René Ngiyulu and Jean-Lambert Gini},
  title = {Clinical Profile and Cardiovascular Risk Factors Among Hemophilians Followed at University Clinics of Kinshasa},
  journal = {European Journal of Clinical and Biomedical Sciences},
  volume = {9},
  number = {3},
  pages = {28-37},
  doi = {10.11648/j.ejcbs.20230903.11},
  url = {https://doi.org/10.11648/j.ejcbs.20230903.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20230903.11},
  abstract = {Background: Hemophilia is a congenital, inherited bleeding disorder that prevents blood from clotting, causing abnormally long bleeding. It remains underdiagnosed in Africa and particularly in the Democratic Republic of Congo, where it remains poorly known to the population and health professionals. The present study aims to determine the clinical profile and cardiovascular risk factors in hemophiliacs at the University Clinics of Kinshasa. Methods: This is a cross-sectional study with an analytical aim, in which 155 patients (children and adults) with a haemorrhagic syndrome were included. The diagnosis of haemophilia was confirmed in thirty-six patients, all male; 22 hemophiliac patients regularly followed were matched with 24 non-hemophilic patients (control group). Results: hemophilia A represented 81% and hemophilia B 19%. The most represented age group was between 3 to 6 years (19%). Regarding the severity of the disease, half of the patients, or 50%, presented with severe hemophilia, the main symptom being hemarthrosis (30%). Of our total sample of hemophiliacs, we had recorded two cases of death (5.5%). Regarding cardiovascular risk factors, only the deterioration of myocardial function was found in one patient (4.5%). Conclusion: hemophilia is a disabling disease, which alters the quality of life of patients. Cardiovascular risk factors seem to be lower in Congolese hemophiliacs, however, ultrasound monitoring is necessary in order to prevent any pejorative evolution.},
 year = {2023}
}

Copy | Download