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Maintenance Therapy with Tegafur-gimeracil-oteracil After First-line Chemotherapy in Stage IV Gastric Cancer: A Retrospective Study

Received: 22 September 2021     Accepted: 15 October 2021     Published: 19 October 2021
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Abstract

Introduction: The feasibility, efficacy and safety of maintenance chemotherapy (MCT) after first-line therapy in advanced gastric cancer (AGC) remain obscure. This study aims to explore the efficacy and safety of tegafur-gimeracil-oteracil MCT in stage IV GC. Methods: Seventeen patients with stage IV GC had been involved in this study from the Department of Oncology of Changhai Hospital from January 1st, 2017 to August 31st, 2021. After 6-8 cycles of first-line chemotherapy with SOX (tegafur-gimeracil-oteracil combined with oxaliplatin) or DS (docetaxel combined with tegafur-gimeracil-oteracil) MCT was administered with tegafur-gimeracil-oteracil which continued until disease progression or intolerable adverse effects or death. The PFS, OS, DCR and adverse effects were analyzed. Results: Among 17 patients with stage IV GC, 11 patients received prior SOX-based first-line therapy, 6 patients with TS regimen. The best curative effect of first-line therapy were CR in 1 case, PR in 2 and SD in 14. DCR was 87.5% after tegafur-gimeracil-oteracil MCT, and the median PFS was 13.5 months, the median OS was 23 months. The main adverse effects of tegafur-gimeracil-oteracil MCT were grade 1-3 hematologic and grade 1 fatigue, gastrointestinal symptoms. There were no treatment-related deaths or toxic effects of grade 4.

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 5)
DOI 10.11648/j.ajcem.20210905.17
Page(s) 168-173
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Gastric Cancer, Tegafur-gimeracil-oteracil, Maintenance Chemotherapy

References
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Cite This Article
  • APA Style

    Kena Zhou, Anjing Zhao, Bin Wang, Jie Li, Yingyi Zhang, et al. (2021). Maintenance Therapy with Tegafur-gimeracil-oteracil After First-line Chemotherapy in Stage IV Gastric Cancer: A Retrospective Study. American Journal of Clinical and Experimental Medicine, 9(5), 168-173. https://doi.org/10.11648/j.ajcem.20210905.17

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    ACS Style

    Kena Zhou; Anjing Zhao; Bin Wang; Jie Li; Yingyi Zhang, et al. Maintenance Therapy with Tegafur-gimeracil-oteracil After First-line Chemotherapy in Stage IV Gastric Cancer: A Retrospective Study. Am. J. Clin. Exp. Med. 2021, 9(5), 168-173. doi: 10.11648/j.ajcem.20210905.17

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    AMA Style

    Kena Zhou, Anjing Zhao, Bin Wang, Jie Li, Yingyi Zhang, et al. Maintenance Therapy with Tegafur-gimeracil-oteracil After First-line Chemotherapy in Stage IV Gastric Cancer: A Retrospective Study. Am J Clin Exp Med. 2021;9(5):168-173. doi: 10.11648/j.ajcem.20210905.17

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  • @article{10.11648/j.ajcem.20210905.17,
      author = {Kena Zhou and Anjing Zhao and Bin Wang and Jie Li and Yingyi Zhang and Meihong Wu and Xianbao Zhan},
      title = {Maintenance Therapy with Tegafur-gimeracil-oteracil After First-line Chemotherapy in Stage IV Gastric Cancer: A Retrospective Study},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {9},
      number = {5},
      pages = {168-173},
      doi = {10.11648/j.ajcem.20210905.17},
      url = {https://doi.org/10.11648/j.ajcem.20210905.17},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210905.17},
      abstract = {Introduction: The feasibility, efficacy and safety of maintenance chemotherapy (MCT) after first-line therapy in advanced gastric cancer (AGC) remain obscure. This study aims to explore the efficacy and safety of tegafur-gimeracil-oteracil MCT in stage IV GC. Methods: Seventeen patients with stage IV GC had been involved in this study from the Department of Oncology of Changhai Hospital from January 1st, 2017 to August 31st, 2021. After 6-8 cycles of first-line chemotherapy with SOX (tegafur-gimeracil-oteracil combined with oxaliplatin) or DS (docetaxel combined with tegafur-gimeracil-oteracil) MCT was administered with tegafur-gimeracil-oteracil which continued until disease progression or intolerable adverse effects or death. The PFS, OS, DCR and adverse effects were analyzed. Results: Among 17 patients with stage IV GC, 11 patients received prior SOX-based first-line therapy, 6 patients with TS regimen. The best curative effect of first-line therapy were CR in 1 case, PR in 2 and SD in 14. DCR was 87.5% after tegafur-gimeracil-oteracil MCT, and the median PFS was 13.5 months, the median OS was 23 months. The main adverse effects of tegafur-gimeracil-oteracil MCT were grade 1-3 hematologic and grade 1 fatigue, gastrointestinal symptoms. There were no treatment-related deaths or toxic effects of grade 4.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Maintenance Therapy with Tegafur-gimeracil-oteracil After First-line Chemotherapy in Stage IV Gastric Cancer: A Retrospective Study
    AU  - Kena Zhou
    AU  - Anjing Zhao
    AU  - Bin Wang
    AU  - Jie Li
    AU  - Yingyi Zhang
    AU  - Meihong Wu
    AU  - Xianbao Zhan
    Y1  - 2021/10/19
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajcem.20210905.17
    DO  - 10.11648/j.ajcem.20210905.17
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 168
    EP  - 173
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20210905.17
    AB  - Introduction: The feasibility, efficacy and safety of maintenance chemotherapy (MCT) after first-line therapy in advanced gastric cancer (AGC) remain obscure. This study aims to explore the efficacy and safety of tegafur-gimeracil-oteracil MCT in stage IV GC. Methods: Seventeen patients with stage IV GC had been involved in this study from the Department of Oncology of Changhai Hospital from January 1st, 2017 to August 31st, 2021. After 6-8 cycles of first-line chemotherapy with SOX (tegafur-gimeracil-oteracil combined with oxaliplatin) or DS (docetaxel combined with tegafur-gimeracil-oteracil) MCT was administered with tegafur-gimeracil-oteracil which continued until disease progression or intolerable adverse effects or death. The PFS, OS, DCR and adverse effects were analyzed. Results: Among 17 patients with stage IV GC, 11 patients received prior SOX-based first-line therapy, 6 patients with TS regimen. The best curative effect of first-line therapy were CR in 1 case, PR in 2 and SD in 14. DCR was 87.5% after tegafur-gimeracil-oteracil MCT, and the median PFS was 13.5 months, the median OS was 23 months. The main adverse effects of tegafur-gimeracil-oteracil MCT were grade 1-3 hematologic and grade 1 fatigue, gastrointestinal symptoms. There were no treatment-related deaths or toxic effects of grade 4.
    VL  - 9
    IS  - 5
    ER  - 

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Author Information
  • Department of Oncology, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, China

  • Department of Oncology, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, China

  • Department of Oncology, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, China

  • Department of Oncology, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, China

  • Department of Oncology, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, China

  • Department of Oncology, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, China

  • Department of Oncology, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, China

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