Process Study on Surface Modification of Coral Hydroxyapatite

Chang Jiahe; Su Jun; Zhang Wenyun

doi:doi:10.11648/j.ajcem.20210905.15

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Process Study on Surface Modification of Coral Hydroxyapatite

Chang Jiahe, Su Jun, Zhang Wenyun

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 5)

Received: 9 September 2021 Accepted: 4 October 2021 Published: 12 October 2021

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Abstract

Objective: To explore process of modifying coral hydroxyapatite by nmZnO under different conditions, the final plan is to develop a porous artificial bone composite that combines the antibacterial properties of nano zinc oxide with the porous biodegradability of coral hydroxyapatite. Methods: Coral hydroxyapatite was modified by zinc nitrate sol-gel method at 70°C in weak acid environment. White granular porous composite materials were obtained by ultrasonic, rotary stirring, drying and calcination. The composition of the composite material is analyzed using X-ray diffractomer (XRD), using scanning electron microscopy (SEM) to observe and analyze changes in the surface appearance of composite materials, using energy dispersive X-ray spectroscopy (EDX) to observe and analyze the composition of the composite surface, the results of thermogravimetric analysis were used to study the decomposition temperature and other characteristics of the composite. Results: The sol-gel method can be used for antibacterial modification on CHA surface. When the mass ratio of coral hydroxyapatite, zinc nitrate and PEG-6000 is 48:4:5, the particle size and distribution of nano-zinc oxide particles are ideal, and uniformly distributed spherical ZnO nanoparticles can be observed under scanning electron microscopy. Conclusion: Coral hydroxyapatite surface could be modified by zinc nitrate sol-gel method. The particle size of nano zinc oxide is less than 100 nanometers. The agglomeration problem of nano-particles is solved; the porous structure of CHA are not destroyed.

Published in	American Journal of Clinical and Experimental Medicine (Volume 9, Issue 5)
DOI	10.11648/j.ajcem.20210905.15
Page(s)	151-156
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Coral Hydroxyapatite, Zinc Oxide, Modification, Antibacterial Property

References

[1]	Xu Ling, Lv Kaige, Zhang Wenjie, et al. The healing of critical-size calvarial bone defects in rat with rhPDGF-BB, BMSCs, and β-TCP scaffolds [J]. Journal of materials science, 2012, 23 (4): 1073-1084.
[2]	Guo Jun, Meng Zhaosong, Chen Gang, et al. Restoration of critical-size defects in the rabbit mandible using porous nanohydroxyapatite-polyamide scaffolds [J]. Tissue engineering, Part A, 2012, 18 (11-12): 1239-1252.
[3]	Rentsch Claudia, Rentsch Barbe, Breier Annette, et al. Long-bone critical-size defects treated with tissue-engineered polycaprolactone-co-lactide scaffolds: a pilot study on rats [J]. Journal of biomedical materials research, Part A, 2010, 95 (3): 964-972.
[4]	N. Mokbel, C. Bou Serhal, G. Matni, et al. Healing patterns of critical size bony defects in rat following bone graft [J]. Oral and maxillofacial surgery, 2008, 12 (2): 73-78.
[5]	Roy D M, Linnehan S K. Hydroxyapatite formed from coral skeletal carbonate by hydrothermal exchange [J]. Nature, 1974, Vol. 247 (5438): 220-222.
[6]	Dodds RA, York - Ely AM, Zhukauskas R, et al. Biomechanical and radiographic comparison of demineralized bone matrix, and a coralline hydroxyapatite in a rabbit spinal fusion model [J]. J Biomater Appl. 2010, 25 (3): 195-215.
[7]	Wasielewski RC, Sheridan KC, Lubbers MA. Coraline hydroxyapatite in complex acetabular reconstruction [J]. Orthopedics, 2008, 31 (4): 367.
[8]	Huo K, Zhang X, Wang H. Osteogenic activity and antibacterial effects on titanium surfaces modified with zn-incorporated nanotube arrays [J]. Biomaterials, 2013; 34 (13): 3467-3478.
[9]	Kasraei S, Sami L, Hendi S. Antibacterial properties of composite resins incorporating silver and zinc oxide nanoparticles on streptococcus mutans and lactobacillus [J]. Restor dent endod, 2014; 39 (2): 109-114.
[10]	Sun Shijia. Preparation and performance study of HAPw/nmZnO-nmCaO antibacterial bone repair materials [D]. Kunming: Master's thesis, Kunming Medical University, 2017.
[11]	Malat TA, Glombitza M, Dahmen J, et al. The use of bioactive glass S53P4 as bone graft substitute in the treatment of chronic osteomyelitis and infected non-unions - a retrospective study of 50 patients [J]. Z Orthop unfall, 2018, Vol. 156 (2): 152-159.
[12]	Tao Cheng, Haiyun Qu, Guoyou Zhang, et al. Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects [J]. Artificial cells, nanomedicine, and biotechnology, 2018, Vol. 46 (8): 1935-1947.
[13]	Wei S, Jian C, Xu F, et al. Vancomycin-impregnated electrospun polycaprolactone (PCL) membrane for the treatment of infected bone defects: An animal study [J]. J Biomater Appl, 2018, 32 (9): 1187-1196.
[14]	Liu D-H, Zhang X-W, Zhang C. Antibiotic abuse and superbugs [J]. Foreign Medicine (Antibiotics Branch), 2019, 40 (1): 1-4.
[15]	Xie X. L., Bai F. Scientists reveal the molecular mechanism of bacterial drug resistance generation [J]. Microbiology Bulletin, 2016, 43 (5): 1164.
[16]	Lindner T, Kanakaris NK, Marx B, et al. Fractures of the hip and osteoporosis: the role of bone substitutes [J]. Bone Joint Surg Br, 2009, 91 (3): 294–303.
[17]	Ji H-B. Analysis of bacterial resistance to antibacterial drugs [J]. Chinese and Foreign Medical Care, 2018, 37 (2): 92-195.
[18]	Xiang R, Ding D-B, Fan L-L, et al. Progress of antibacterial mechanism of zinc oxide and its safety research [J]. Chinese Tissue Engineering Research, 2014, 18 (3): 470-475.
[19]	Fu Kun, Xu Qingguo, Czernuszka Jan, et al. Characterization of a biodegradable coralline hydroxyapatite/calcium carbonate composite and its clinical implementation [J]. Biomedical materials, 2013, 8 (6): 1327-1329.
[20]	Chen Zepeng, Zhang Ying, Lin Zefeng, et al. Imaging evaluation of dextran sulfate/recombinant human BMP-2/chitosan composite microspheres combined with coral hydroxyapatite artificial bone for repairing large segmental bone defects [J]. Chinese Journal of Restorative and Reconstructive Surgery, 2017, 31 (11): 1384-1389.
[21]	Liu Chang. Study on in vitro degradation of coral hydroxyapatite with different replacement rates [D]. Zhengzhou: Master's thesis, Zhengzhou University, 2016.
[22]	Hak DJ. The use of osteoconductive bone graft substitutes in orthopaedic trauma [J]. The journal of the american academy of orthopaedic surgeons, 2007, Vol. 15 (9): 525-536.
[23]	Sun Shijia, Zhao Qiang, Yuan Yanbo, et al. Study on the effect of pH on the morphology of HAPw-nmZnO-nmCaO composite biomaterials [J]. Journal of Dental Research, 2017, 33 (6): 585-588.
[24]	Zeng Xianli. Study on the antifungal mechanism of zinc oxide nanoparticles [D]. Zhuzhou: Master's thesis, Hunan University of Technology, 2017.
[25]	Mladenovic Z, Sahlin-Platt A, Andersson B, et al. In vitro study of the biological interface of bio-oss: implications of the experimental setup [J]. Clinical oral implants research, 2013, Vol. 24 (3): 329-335.
[26]	El-Ghannam A, Ning C Q. Effect of bioactive ceramic dissolution on the mechanism of bone mineralization and guided tissue growth in vitro [J]. Journal of biomedical materials research. Part A, 2006, Vol. 76 (2): 386-397.
[27]	Beck George R. Inorganic phosphate as a signaling molecule in osteoblast differentiation [J]. Journal of cellular biochemistry, 2003, 90 (2): 234-243.

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APA Style

Chang Jiahe, Su Jun, Zhang Wenyun. (2021). Process Study on Surface Modification of Coral Hydroxyapatite. American Journal of Clinical and Experimental Medicine, 9(5), 151-156. https://doi.org/10.11648/j.ajcem.20210905.15

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ACS Style

Chang Jiahe; Su Jun; Zhang Wenyun. Process Study on Surface Modification of Coral Hydroxyapatite. Am. J. Clin. Exp. Med. 2021, 9(5), 151-156. doi: 10.11648/j.ajcem.20210905.15

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AMA Style

Chang Jiahe, Su Jun, Zhang Wenyun. Process Study on Surface Modification of Coral Hydroxyapatite. Am J Clin Exp Med. 2021;9(5):151-156. doi: 10.11648/j.ajcem.20210905.15

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@article{10.11648/j.ajcem.20210905.15,
  author = {Chang Jiahe and Su Jun and Zhang Wenyun},
  title = {Process Study on Surface Modification of Coral Hydroxyapatite},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {5},
  pages = {151-156},
  doi = {10.11648/j.ajcem.20210905.15},
  url = {https://doi.org/10.11648/j.ajcem.20210905.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210905.15},
  abstract = {Objective: To explore process of modifying coral hydroxyapatite by nmZnO under different conditions, the final plan is to develop a porous artificial bone composite that combines the antibacterial properties of nano zinc oxide with the porous biodegradability of coral hydroxyapatite. Methods: Coral hydroxyapatite was modified by zinc nitrate sol-gel method at 70°C in weak acid environment. White granular porous composite materials were obtained by ultrasonic, rotary stirring, drying and calcination. The composition of the composite material is analyzed using X-ray diffractomer (XRD), using scanning electron microscopy (SEM) to observe and analyze changes in the surface appearance of composite materials, using energy dispersive X-ray spectroscopy (EDX) to observe and analyze the composition of the composite surface, the results of thermogravimetric analysis were used to study the decomposition temperature and other characteristics of the composite. Results: The sol-gel method can be used for antibacterial modification on CHA surface. When the mass ratio of coral hydroxyapatite, zinc nitrate and PEG-6000 is 48:4:5, the particle size and distribution of nano-zinc oxide particles are ideal, and uniformly distributed spherical ZnO nanoparticles can be observed under scanning electron microscopy. Conclusion: Coral hydroxyapatite surface could be modified by zinc nitrate sol-gel method. The particle size of nano zinc oxide is less than 100 nanometers. The agglomeration problem of nano-particles is solved; the porous structure of CHA are not destroyed.},
 year = {2021}
}

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TY  - JOUR
T1  - Process Study on Surface Modification of Coral Hydroxyapatite
AU  - Chang Jiahe
AU  - Su Jun
AU  - Zhang Wenyun
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210905.15
DO  - 10.11648/j.ajcem.20210905.15
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 151
EP  - 156
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210905.15
AB  - Objective: To explore process of modifying coral hydroxyapatite by nmZnO under different conditions, the final plan is to develop a porous artificial bone composite that combines the antibacterial properties of nano zinc oxide with the porous biodegradability of coral hydroxyapatite. Methods: Coral hydroxyapatite was modified by zinc nitrate sol-gel method at 70°C in weak acid environment. White granular porous composite materials were obtained by ultrasonic, rotary stirring, drying and calcination. The composition of the composite material is analyzed using X-ray diffractomer (XRD), using scanning electron microscopy (SEM) to observe and analyze changes in the surface appearance of composite materials, using energy dispersive X-ray spectroscopy (EDX) to observe and analyze the composition of the composite surface, the results of thermogravimetric analysis were used to study the decomposition temperature and other characteristics of the composite. Results: The sol-gel method can be used for antibacterial modification on CHA surface. When the mass ratio of coral hydroxyapatite, zinc nitrate and PEG-6000 is 48:4:5, the particle size and distribution of nano-zinc oxide particles are ideal, and uniformly distributed spherical ZnO nanoparticles can be observed under scanning electron microscopy. Conclusion: Coral hydroxyapatite surface could be modified by zinc nitrate sol-gel method. The particle size of nano zinc oxide is less than 100 nanometers. The agglomeration problem of nano-particles is solved; the porous structure of CHA are not destroyed.
VL  - 9
IS  - 5
ER  -

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Author Information

Chang Jiahe

Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China
Su Jun

Department of Stomatology, No. 920 Hospital of PLA, Kunming Medical University, Kunming, China
Zhang Wenyun

Department of Stomatology, No. 920 Hospital of PLA, Kunming Medical University, Kunming, China

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Plain Text BibTeX RIS

APA Style

Chang Jiahe, Su Jun, Zhang Wenyun. (2021). Process Study on Surface Modification of Coral Hydroxyapatite. American Journal of Clinical and Experimental Medicine, 9(5), 151-156. https://doi.org/10.11648/j.ajcem.20210905.15

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ACS Style

Chang Jiahe; Su Jun; Zhang Wenyun. Process Study on Surface Modification of Coral Hydroxyapatite. Am. J. Clin. Exp. Med. 2021, 9(5), 151-156. doi: 10.11648/j.ajcem.20210905.15

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AMA Style

Chang Jiahe, Su Jun, Zhang Wenyun. Process Study on Surface Modification of Coral Hydroxyapatite. Am J Clin Exp Med. 2021;9(5):151-156. doi: 10.11648/j.ajcem.20210905.15

Copy | Download

@article{10.11648/j.ajcem.20210905.15,
  author = {Chang Jiahe and Su Jun and Zhang Wenyun},
  title = {Process Study on Surface Modification of Coral Hydroxyapatite},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {5},
  pages = {151-156},
  doi = {10.11648/j.ajcem.20210905.15},
  url = {https://doi.org/10.11648/j.ajcem.20210905.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210905.15},
  abstract = {Objective: To explore process of modifying coral hydroxyapatite by nmZnO under different conditions, the final plan is to develop a porous artificial bone composite that combines the antibacterial properties of nano zinc oxide with the porous biodegradability of coral hydroxyapatite. Methods: Coral hydroxyapatite was modified by zinc nitrate sol-gel method at 70°C in weak acid environment. White granular porous composite materials were obtained by ultrasonic, rotary stirring, drying and calcination. The composition of the composite material is analyzed using X-ray diffractomer (XRD), using scanning electron microscopy (SEM) to observe and analyze changes in the surface appearance of composite materials, using energy dispersive X-ray spectroscopy (EDX) to observe and analyze the composition of the composite surface, the results of thermogravimetric analysis were used to study the decomposition temperature and other characteristics of the composite. Results: The sol-gel method can be used for antibacterial modification on CHA surface. When the mass ratio of coral hydroxyapatite, zinc nitrate and PEG-6000 is 48:4:5, the particle size and distribution of nano-zinc oxide particles are ideal, and uniformly distributed spherical ZnO nanoparticles can be observed under scanning electron microscopy. Conclusion: Coral hydroxyapatite surface could be modified by zinc nitrate sol-gel method. The particle size of nano zinc oxide is less than 100 nanometers. The agglomeration problem of nano-particles is solved; the porous structure of CHA are not destroyed.},
 year = {2021}
}

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TY  - JOUR
T1  - Process Study on Surface Modification of Coral Hydroxyapatite
AU  - Chang Jiahe
AU  - Su Jun
AU  - Zhang Wenyun
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210905.15
DO  - 10.11648/j.ajcem.20210905.15
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 151
EP  - 156
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210905.15
AB  - Objective: To explore process of modifying coral hydroxyapatite by nmZnO under different conditions, the final plan is to develop a porous artificial bone composite that combines the antibacterial properties of nano zinc oxide with the porous biodegradability of coral hydroxyapatite. Methods: Coral hydroxyapatite was modified by zinc nitrate sol-gel method at 70°C in weak acid environment. White granular porous composite materials were obtained by ultrasonic, rotary stirring, drying and calcination. The composition of the composite material is analyzed using X-ray diffractomer (XRD), using scanning electron microscopy (SEM) to observe and analyze changes in the surface appearance of composite materials, using energy dispersive X-ray spectroscopy (EDX) to observe and analyze the composition of the composite surface, the results of thermogravimetric analysis were used to study the decomposition temperature and other characteristics of the composite. Results: The sol-gel method can be used for antibacterial modification on CHA surface. When the mass ratio of coral hydroxyapatite, zinc nitrate and PEG-6000 is 48:4:5, the particle size and distribution of nano-zinc oxide particles are ideal, and uniformly distributed spherical ZnO nanoparticles can be observed under scanning electron microscopy. Conclusion: Coral hydroxyapatite surface could be modified by zinc nitrate sol-gel method. The particle size of nano zinc oxide is less than 100 nanometers. The agglomeration problem of nano-particles is solved; the porous structure of CHA are not destroyed.
VL  - 9
IS  - 5
ER  -

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