The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction

Hou Zhenjiang; Mu Zhaoxin; Zhang Jingyu; Fan Hong; Hou Jianzhang

doi:doi:10.11648/j.ajcem.20170504.12

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The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang

Published in American Journal of Clinical and Experimental Medicine (Volume 5, Issue 4)

Received: 19 May 2017 Published: 6 June 2017

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Abstract

This thesis aims to discuss the correlation of blood lipid and its ratio, Cystatin C(CysC) and Homocysteine (Hcy) of thyroid dysfunction patients, who are hyperthyroidism, subclinical hyperthyroidism, hypothyroidism and subclinical hypothyroidism. The authors choose each 60 patients of four groups of thyroid dysfunction and the control group to measure the serum TH, blood lipid, CysC and Hcy and calculate and analyze blood lipid ratio. As a result, on the one hand, TC, TG, LDL-C of hyperthyroidism and subclinical hyperthyroidism group are obviously lower than the control group, TC/HDL-C and TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C of hyperthyroidism are significantly lower than the hyperthyroidism and the control group. LDL-C/HDL-C, and TC/HDL-C and TG/HDL-C of subclinical hyperthyroidism significantly reduce, and especially LCI is significant. The followings are LDL-C/HDL-C, nevertheless TC/HDL-C, TG/HDL-C are higher than the control group. On the other hand, TC, TG, LDL-C, TG/HDL-C, LDL-C/ HDL-C, LCI and non-HDL-C of hypothyroidism are prominently higher than the subclinical hypothyroidism and the control group. TC, TG and LDL-C, LDL-C/HDL-C and non-HDL-C of the subclinical hypothyroidism are higher than the control group. HDL-C is lower than the control group. TC has the highest relevance in various kinds of TH and the followings are respectively: non-HDL-C, LDL-C and LCI. CysC of hyperthyroidism and subclinical hyperthyroidism group obviously increases, whereas Hcy decreases. CysC of hypothyroidism and subclinical hypothyroidism group obviously decreases, whereas Hcy increases. According to the results, the authors come to the conclusion that the change of blood lipid ratio of subclinical thyroid dysfunction is more obvious than the index of single blood lipid and the CysC and Hcy also corresponding change. Dynamic monitoring TSH, blood lipid ratio, CysC and Hcy has an important value of transforming from subclinical thyroid dysfunction to clinical dysfunction and prediction of concurrent CVD. Joint detection is expected to become the ideal optimization combination of project.

Published in	American Journal of Clinical and Experimental Medicine (Volume 5, Issue 4)
DOI	10.11648/j.ajcem.20170504.12
Page(s)	108-114
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Thyroid Dysfunction, Thyroid Hormones, Blood Lipid Profile, Blood Lipid Ratio, Cystatin C, Homocysteine

References

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APA Style

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang. (2017). The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction. American Journal of Clinical and Experimental Medicine, 5(4), 108-114. https://doi.org/10.11648/j.ajcem.20170504.12

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ACS Style

Hou Zhenjiang; Mu Zhaoxin; Zhang Jingyu; Fan Hong; Hou Jianzhang. The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction. Am. J. Clin. Exp. Med. 2017, 5(4), 108-114. doi: 10.11648/j.ajcem.20170504.12

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AMA Style

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang. The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction. Am J Clin Exp Med. 2017;5(4):108-114. doi: 10.11648/j.ajcem.20170504.12

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@article{10.11648/j.ajcem.20170504.12,
  author = {Hou Zhenjiang and Mu Zhaoxin and Zhang Jingyu and Fan Hong and Hou Jianzhang},
  title = {The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {4},
  pages = {108-114},
  doi = {10.11648/j.ajcem.20170504.12},
  url = {https://doi.org/10.11648/j.ajcem.20170504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170504.12},
  abstract = {This thesis aims to discuss the correlation of blood lipid and its ratio, Cystatin C(CysC) and Homocysteine (Hcy) of thyroid dysfunction patients, who are hyperthyroidism, subclinical hyperthyroidism, hypothyroidism and subclinical hypothyroidism. The authors choose each 60 patients of four groups of thyroid dysfunction and the control group to measure the serum TH, blood lipid, CysC and Hcy and calculate and analyze blood lipid ratio. As a result, on the one hand, TC, TG, LDL-C of hyperthyroidism and subclinical hyperthyroidism group are obviously lower than the control group, TC/HDL-C and TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C of hyperthyroidism are significantly lower than the hyperthyroidism and the control group. LDL-C/HDL-C, and TC/HDL-C and TG/HDL-C of subclinical hyperthyroidism significantly reduce, and especially LCI is significant. The followings are LDL-C/HDL-C, nevertheless TC/HDL-C, TG/HDL-C are higher than the control group. On the other hand, TC, TG, LDL-C, TG/HDL-C, LDL-C/ HDL-C, LCI and non-HDL-C of hypothyroidism are prominently higher than the subclinical hypothyroidism and the control group. TC, TG and LDL-C, LDL-C/HDL-C and non-HDL-C of the subclinical hypothyroidism are higher than the control group. HDL-C is lower than the control group. TC has the highest relevance in various kinds of TH and the followings are respectively: non-HDL-C, LDL-C and LCI. CysC of hyperthyroidism and subclinical hyperthyroidism group obviously increases, whereas Hcy decreases. CysC of hypothyroidism and subclinical hypothyroidism group obviously decreases, whereas Hcy increases. According to the results, the authors come to the conclusion that the change of blood lipid ratio of subclinical thyroid dysfunction is more obvious than the index of single blood lipid and the CysC and Hcy also corresponding change. Dynamic monitoring TSH, blood lipid ratio, CysC and Hcy has an important value of transforming from subclinical thyroid dysfunction to clinical dysfunction and prediction of concurrent CVD. Joint detection is expected to become the ideal optimization combination of project.},
 year = {2017}
}

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TY - JOUR
T1 - The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction
AU - Hou Zhenjiang
AU - Mu Zhaoxin
AU - Zhang Jingyu
AU - Fan Hong
AU - Hou Jianzhang
Y1 - 2017/06/06
PY - 2017
N1 - https://doi.org/10.11648/j.ajcem.20170504.12
DO - 10.11648/j.ajcem.20170504.12
T2 - American Journal of Clinical and Experimental Medicine
JF - American Journal of Clinical and Experimental Medicine
JO - American Journal of Clinical and Experimental Medicine
SP - 108
EP - 114
PB - Science Publishing Group
SN - 2330-8133
UR - https://doi.org/10.11648/j.ajcem.20170504.12
AB - This thesis aims to discuss the correlation of blood lipid and its ratio, Cystatin C(CysC) and Homocysteine (Hcy) of thyroid dysfunction patients, who are hyperthyroidism, subclinical hyperthyroidism, hypothyroidism and subclinical hypothyroidism. The authors choose each 60 patients of four groups of thyroid dysfunction and the control group to measure the serum TH, blood lipid, CysC and Hcy and calculate and analyze blood lipid ratio. As a result, on the one hand, TC, TG, LDL-C of hyperthyroidism and subclinical hyperthyroidism group are obviously lower than the control group, TC/HDL-C and TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C of hyperthyroidism are significantly lower than the hyperthyroidism and the control group. LDL-C/HDL-C, and TC/HDL-C and TG/HDL-C of subclinical hyperthyroidism significantly reduce, and especially LCI is significant. The followings are LDL-C/HDL-C, nevertheless TC/HDL-C, TG/HDL-C are higher than the control group. On the other hand, TC, TG, LDL-C, TG/HDL-C, LDL-C/ HDL-C, LCI and non-HDL-C of hypothyroidism are prominently higher than the subclinical hypothyroidism and the control group. TC, TG and LDL-C, LDL-C/HDL-C and non-HDL-C of the subclinical hypothyroidism are higher than the control group. HDL-C is lower than the control group. TC has the highest relevance in various kinds of TH and the followings are respectively: non-HDL-C, LDL-C and LCI. CysC of hyperthyroidism and subclinical hyperthyroidism group obviously increases, whereas Hcy decreases. CysC of hypothyroidism and subclinical hypothyroidism group obviously decreases, whereas Hcy increases. According to the results, the authors come to the conclusion that the change of blood lipid ratio of subclinical thyroid dysfunction is more obvious than the index of single blood lipid and the CysC and Hcy also corresponding change. Dynamic monitoring TSH, blood lipid ratio, CysC and Hcy has an important value of transforming from subclinical thyroid dysfunction to clinical dysfunction and prediction of concurrent CVD. Joint detection is expected to become the ideal optimization combination of project.
VL - 5
IS - 4
ER -

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Author Information

Hou Zhenjiang

Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Mu Zhaoxin

Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Zhang Jingyu

Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Fan Hong

Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Hou Jianzhang

Department of Surgery, Cangzhou People's Hospital, Cangzhou Medical College, Cangzhou, China

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APA Style

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang. (2017). The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction. American Journal of Clinical and Experimental Medicine, 5(4), 108-114. https://doi.org/10.11648/j.ajcem.20170504.12

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ACS Style

Hou Zhenjiang; Mu Zhaoxin; Zhang Jingyu; Fan Hong; Hou Jianzhang. The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction. Am. J. Clin. Exp. Med. 2017, 5(4), 108-114. doi: 10.11648/j.ajcem.20170504.12

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AMA Style

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang. The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction. Am J Clin Exp Med. 2017;5(4):108-114. doi: 10.11648/j.ajcem.20170504.12

Copy | Download

@article{10.11648/j.ajcem.20170504.12,
  author = {Hou Zhenjiang and Mu Zhaoxin and Zhang Jingyu and Fan Hong and Hou Jianzhang},
  title = {The Correlation of Blood Lipid Profile and its Ratio, Cystatin C and Homocysteine of Thyroid Dysfunction},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {4},
  pages = {108-114},
  doi = {10.11648/j.ajcem.20170504.12},
  url = {https://doi.org/10.11648/j.ajcem.20170504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170504.12},
  abstract = {This thesis aims to discuss the correlation of blood lipid and its ratio, Cystatin C(CysC) and Homocysteine (Hcy) of thyroid dysfunction patients, who are hyperthyroidism, subclinical hyperthyroidism, hypothyroidism and subclinical hypothyroidism. The authors choose each 60 patients of four groups of thyroid dysfunction and the control group to measure the serum TH, blood lipid, CysC and Hcy and calculate and analyze blood lipid ratio. As a result, on the one hand, TC, TG, LDL-C of hyperthyroidism and subclinical hyperthyroidism group are obviously lower than the control group, TC/HDL-C and TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C of hyperthyroidism are significantly lower than the hyperthyroidism and the control group. LDL-C/HDL-C, and TC/HDL-C and TG/HDL-C of subclinical hyperthyroidism significantly reduce, and especially LCI is significant. The followings are LDL-C/HDL-C, nevertheless TC/HDL-C, TG/HDL-C are higher than the control group. On the other hand, TC, TG, LDL-C, TG/HDL-C, LDL-C/ HDL-C, LCI and non-HDL-C of hypothyroidism are prominently higher than the subclinical hypothyroidism and the control group. TC, TG and LDL-C, LDL-C/HDL-C and non-HDL-C of the subclinical hypothyroidism are higher than the control group. HDL-C is lower than the control group. TC has the highest relevance in various kinds of TH and the followings are respectively: non-HDL-C, LDL-C and LCI. CysC of hyperthyroidism and subclinical hyperthyroidism group obviously increases, whereas Hcy decreases. CysC of hypothyroidism and subclinical hypothyroidism group obviously decreases, whereas Hcy increases. According to the results, the authors come to the conclusion that the change of blood lipid ratio of subclinical thyroid dysfunction is more obvious than the index of single blood lipid and the CysC and Hcy also corresponding change. Dynamic monitoring TSH, blood lipid ratio, CysC and Hcy has an important value of transforming from subclinical thyroid dysfunction to clinical dysfunction and prediction of concurrent CVD. Joint detection is expected to become the ideal optimization combination of project.},
 year = {2017}
}

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