This research aims to determine the effect of topical cocoa extract application through ekspression of Bcl-2 and MDA on albino mice skin that induced by DMBA-TPA. The research was conducted at Animal Laboratory for application of DMBA, MDA-TPA and cocoa extract and Biomolecular Laboratory of Medical Faculty of Hasanuddin University Makassar as the place of ELISA examination. The method used was animal experimental with pure experimental design to know the role of topical cocoa extract towards the skin of mice which has been given DMBA-TPA three times a week in 12 weeks. The research unit was the skin of the back side of albino mice which have been excised and divided into 5 groups of treatment. The results indicate that extract of concentration cocoa 400 ppm (p<0.05) which is applied every day has the highest effects decreased of Bcl-2 and MDA expression after being inducted by DMBA-TPA three times a week.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 5, Issue 3) |
| DOI | 10.11648/j.ajcem.20170503.16 |
| Page(s) | 97-101 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Bcl-2, Cacao Extract, DMBA, Malondialdehyde (MDA), TPA
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APA Style
Khairuddin Djawad, Munawar Ambar, Siswanto Wahab. (2017). Chemopreventive Effects of Cocoa Extract Application Towards Expression of Bcl-2 and Mda on Albino Mice Skin Induced by Dmba-Tpa. American Journal of Clinical and Experimental Medicine, 5(3), 97-101. https://doi.org/10.11648/j.ajcem.20170503.16
ACS Style
Khairuddin Djawad; Munawar Ambar; Siswanto Wahab. Chemopreventive Effects of Cocoa Extract Application Towards Expression of Bcl-2 and Mda on Albino Mice Skin Induced by Dmba-Tpa. Am. J. Clin. Exp. Med. 2017, 5(3), 97-101. doi: 10.11648/j.ajcem.20170503.16
AMA Style
Khairuddin Djawad, Munawar Ambar, Siswanto Wahab. Chemopreventive Effects of Cocoa Extract Application Towards Expression of Bcl-2 and Mda on Albino Mice Skin Induced by Dmba-Tpa. Am J Clin Exp Med. 2017;5(3):97-101. doi: 10.11648/j.ajcem.20170503.16
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Download@article{10.11648/j.ajcem.20170503.16,
author = {Khairuddin Djawad and Munawar Ambar and Siswanto Wahab},
title = {Chemopreventive Effects of Cocoa Extract Application Towards Expression of Bcl-2 and Mda on Albino Mice Skin Induced by Dmba-Tpa},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {5},
number = {3},
pages = {97-101},
doi = {10.11648/j.ajcem.20170503.16},
url = {https://doi.org/10.11648/j.ajcem.20170503.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170503.16},
abstract = {This research aims to determine the effect of topical cocoa extract application through ekspression of Bcl-2 and MDA on albino mice skin that induced by DMBA-TPA. The research was conducted at Animal Laboratory for application of DMBA, MDA-TPA and cocoa extract and Biomolecular Laboratory of Medical Faculty of Hasanuddin University Makassar as the place of ELISA examination. The method used was animal experimental with pure experimental design to know the role of topical cocoa extract towards the skin of mice which has been given DMBA-TPA three times a week in 12 weeks. The research unit was the skin of the back side of albino mice which have been excised and divided into 5 groups of treatment. The results indicate that extract of concentration cocoa 400 ppm (p<0.05) which is applied every day has the highest effects decreased of Bcl-2 and MDA expression after being inducted by DMBA-TPA three times a week.},
year = {2017}
}
TY - JOUR T1 - Chemopreventive Effects of Cocoa Extract Application Towards Expression of Bcl-2 and Mda on Albino Mice Skin Induced by Dmba-Tpa AU - Khairuddin Djawad AU - Munawar Ambar AU - Siswanto Wahab Y1 - 2017/05/18 PY - 2017 N1 - https://doi.org/10.11648/j.ajcem.20170503.16 DO - 10.11648/j.ajcem.20170503.16 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 97 EP - 101 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20170503.16 AB - This research aims to determine the effect of topical cocoa extract application through ekspression of Bcl-2 and MDA on albino mice skin that induced by DMBA-TPA. The research was conducted at Animal Laboratory for application of DMBA, MDA-TPA and cocoa extract and Biomolecular Laboratory of Medical Faculty of Hasanuddin University Makassar as the place of ELISA examination. The method used was animal experimental with pure experimental design to know the role of topical cocoa extract towards the skin of mice which has been given DMBA-TPA three times a week in 12 weeks. The research unit was the skin of the back side of albino mice which have been excised and divided into 5 groups of treatment. The results indicate that extract of concentration cocoa 400 ppm (p<0.05) which is applied every day has the highest effects decreased of Bcl-2 and MDA expression after being inducted by DMBA-TPA three times a week. VL - 5 IS - 3 ER -
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