Background: Thyroid dysfunction may be associated in pediatric SLE cases and may present as euthyroid, subclinical hypothyroid, hypothyroid or hyperthyroid states. Aim of this study was to assess thyroid functions (serum T3, T4, TSH) and thyroid antibodies (anti-thyroid Peroxidase and anti-thyroglobulin) in pediatric SLE patients. Methods: It was a cross sectional study. Pediatric SLE (pSLE) patients who fulfilled the American College of Rheumatology 1997 revised classification criteria for SLE were enrolled in this study. Sixteen apparently healthy children were enrolled in the study as reference group. Disease activity was measured by systemic lupus erythematosus disease activity index (SLEDAI). Serum T3, T4, TSH and auto-antibodies including, anti-thyroid peroxidase (anti-TPO) and anti- thyroglobulin (anti-TG) were measured by radio-immuno assay (RIA) method in the National Institute of Nuclear Medicine & Allied Sciences, BSMMU, Dhaka. Data were analyzed by SPSS for window version 16 which included descriptive statistics, Man-Whitney test and Fisher exact test. Results: Among a total number of 50 pSLE cases, 41 (82%) cases had euthyroid state, 4 had subclinical hypothyroidism, 3 had hypothyroidism and 2 patients had euthyroid sick syndrome. All the cases of reference group were in euthyroid state. Anti-thyroid peroxidase (TPO) antibody was positive in 24 pSLE cases and anti-thyroglobulin (TG) antibody was positive in 16 patients. Thyroid disorder was present in 9 cases and 7 of them had positive anti-TPO antibody. Conclusion: Thyroid disorders and presence of thyroid auto antibodies were common in pSLE patients. Anti-TPO positivity was more common than Anti-TG positivity
| Published in | American Journal of Clinical and Experimental Medicine (Volume 3, Issue 5) |
| DOI | 10.11648/j.ajcem.20150305.12 |
| Page(s) | 207-212 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Pediatric SLE, Triidothyronine, Thyroxine, TSH, Anti- thyroid Peroxidase, Anti- thyroglobulin
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APA Style
Satya Narayan Chaudhary, Shahana Akther Rahman, Mohammad Imnul Islam, Suraiya Begum, Manik Kumar Talukdar, et al. (2015). Thyroid Functions and Thyroid Auto-Antibodies in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. American Journal of Clinical and Experimental Medicine, 3(5), 207-212. https://doi.org/10.11648/j.ajcem.20150305.12
ACS Style
Satya Narayan Chaudhary; Shahana Akther Rahman; Mohammad Imnul Islam; Suraiya Begum; Manik Kumar Talukdar, et al. Thyroid Functions and Thyroid Auto-Antibodies in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. Am. J. Clin. Exp. Med. 2015, 3(5), 207-212. doi: 10.11648/j.ajcem.20150305.12
AMA Style
Satya Narayan Chaudhary, Shahana Akther Rahman, Mohammad Imnul Islam, Suraiya Begum, Manik Kumar Talukdar, et al. Thyroid Functions and Thyroid Auto-Antibodies in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. Am J Clin Exp Med. 2015;3(5):207-212. doi: 10.11648/j.ajcem.20150305.12
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Download@article{10.11648/j.ajcem.20150305.12,
author = {Satya Narayan Chaudhary and Shahana Akther Rahman and Mohammad Imnul Islam and Suraiya Begum and Manik Kumar Talukdar and Md Israque Hossain Ansari and Mizanul Hasan},
title = {Thyroid Functions and Thyroid Auto-Antibodies in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {3},
number = {5},
pages = {207-212},
doi = {10.11648/j.ajcem.20150305.12},
url = {https://doi.org/10.11648/j.ajcem.20150305.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150305.12},
abstract = {Background: Thyroid dysfunction may be associated in pediatric SLE cases and may present as euthyroid, subclinical hypothyroid, hypothyroid or hyperthyroid states. Aim of this study was to assess thyroid functions (serum T3, T4, TSH) and thyroid antibodies (anti-thyroid Peroxidase and anti-thyroglobulin) in pediatric SLE patients. Methods: It was a cross sectional study. Pediatric SLE (pSLE) patients who fulfilled the American College of Rheumatology 1997 revised classification criteria for SLE were enrolled in this study. Sixteen apparently healthy children were enrolled in the study as reference group. Disease activity was measured by systemic lupus erythematosus disease activity index (SLEDAI). Serum T3, T4, TSH and auto-antibodies including, anti-thyroid peroxidase (anti-TPO) and anti- thyroglobulin (anti-TG) were measured by radio-immuno assay (RIA) method in the National Institute of Nuclear Medicine & Allied Sciences, BSMMU, Dhaka. Data were analyzed by SPSS for window version 16 which included descriptive statistics, Man-Whitney test and Fisher exact test. Results: Among a total number of 50 pSLE cases, 41 (82%) cases had euthyroid state, 4 had subclinical hypothyroidism, 3 had hypothyroidism and 2 patients had euthyroid sick syndrome. All the cases of reference group were in euthyroid state. Anti-thyroid peroxidase (TPO) antibody was positive in 24 pSLE cases and anti-thyroglobulin (TG) antibody was positive in 16 patients. Thyroid disorder was present in 9 cases and 7 of them had positive anti-TPO antibody. Conclusion: Thyroid disorders and presence of thyroid auto antibodies were common in pSLE patients. Anti-TPO positivity was more common than Anti-TG positivity},
year = {2015}
}
TY - JOUR T1 - Thyroid Functions and Thyroid Auto-Antibodies in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh AU - Satya Narayan Chaudhary AU - Shahana Akther Rahman AU - Mohammad Imnul Islam AU - Suraiya Begum AU - Manik Kumar Talukdar AU - Md Israque Hossain Ansari AU - Mizanul Hasan Y1 - 2015/08/21 PY - 2015 N1 - https://doi.org/10.11648/j.ajcem.20150305.12 DO - 10.11648/j.ajcem.20150305.12 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 207 EP - 212 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20150305.12 AB - Background: Thyroid dysfunction may be associated in pediatric SLE cases and may present as euthyroid, subclinical hypothyroid, hypothyroid or hyperthyroid states. Aim of this study was to assess thyroid functions (serum T3, T4, TSH) and thyroid antibodies (anti-thyroid Peroxidase and anti-thyroglobulin) in pediatric SLE patients. Methods: It was a cross sectional study. Pediatric SLE (pSLE) patients who fulfilled the American College of Rheumatology 1997 revised classification criteria for SLE were enrolled in this study. Sixteen apparently healthy children were enrolled in the study as reference group. Disease activity was measured by systemic lupus erythematosus disease activity index (SLEDAI). Serum T3, T4, TSH and auto-antibodies including, anti-thyroid peroxidase (anti-TPO) and anti- thyroglobulin (anti-TG) were measured by radio-immuno assay (RIA) method in the National Institute of Nuclear Medicine & Allied Sciences, BSMMU, Dhaka. Data were analyzed by SPSS for window version 16 which included descriptive statistics, Man-Whitney test and Fisher exact test. Results: Among a total number of 50 pSLE cases, 41 (82%) cases had euthyroid state, 4 had subclinical hypothyroidism, 3 had hypothyroidism and 2 patients had euthyroid sick syndrome. All the cases of reference group were in euthyroid state. Anti-thyroid peroxidase (TPO) antibody was positive in 24 pSLE cases and anti-thyroglobulin (TG) antibody was positive in 16 patients. Thyroid disorder was present in 9 cases and 7 of them had positive anti-TPO antibody. Conclusion: Thyroid disorders and presence of thyroid auto antibodies were common in pSLE patients. Anti-TPO positivity was more common than Anti-TG positivity VL - 3 IS - 5 ER -
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