Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis

Torricelli Piera; Antonelli Francesco; Ferorelli Pasquale; De Martino Angelo; Shevchenko Anna; Beninati Simone

doi:doi:10.11648/j.ajcem.20150303.12

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Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis

Torricelli Piera, Antonelli Francesco, Ferorelli Pasquale, De Martino Angelo, Shevchenko Anna, Beninati Simone

Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 3)

Received: 26 March 2015 Accepted: 9 April 2015 Published: 18 April 2015

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Abstract

In the pathogenesis of demyelinating diseases including multiple sclerosis (MS) an important role is played by oxidative stress. Increased energy requirements during remyelination of axons and mitochondria failure is one of the causes of axonal degeneration and disability in MS. In the presence of neurological diseases such as MS, F2-isoprostanes are concentrated in higher quantities. In this context, we analyzed the levels of F2-isoprostanes in the plasma and cerebrospinal fluid of mice of the strain C57BL6/N with an induced experimental autoimmune encephalomyelitis (EAE), orally treated with two concentrations of Citozym, a dietary supplement with evident antioxidant properties. Compared to the control group, Citozym-treated EAE-mouse had significantly lower levels of F2-isoprostanes both in plasma and in cerebrospinal fluid. Furthermore, according to the guidelines of IACUC, treatment with Citozym at higher concentrations drastically reduced neurological signs of induced EAE.

Published in	American Journal of Clinical and Experimental Medicine (Volume 3, Issue 3)
DOI	10.11648/j.ajcem.20150303.12
Page(s)	83-87
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Food Supplements, Antioxidants, Multiple Sclerosis, F2-Isoprostanes, Oxidative Stress

References

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APA Style

Torricelli Piera, Antonelli Francesco, Ferorelli Pasquale, De Martino Angelo, Shevchenko Anna, et al. (2015). Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis. American Journal of Clinical and Experimental Medicine, 3(3), 83-87. https://doi.org/10.11648/j.ajcem.20150303.12

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ACS Style

Torricelli Piera; Antonelli Francesco; Ferorelli Pasquale; De Martino Angelo; Shevchenko Anna, et al. Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis. Am. J. Clin. Exp. Med. 2015, 3(3), 83-87. doi: 10.11648/j.ajcem.20150303.12

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AMA Style

Torricelli Piera, Antonelli Francesco, Ferorelli Pasquale, De Martino Angelo, Shevchenko Anna, et al. Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis. Am J Clin Exp Med. 2015;3(3):83-87. doi: 10.11648/j.ajcem.20150303.12

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@article{10.11648/j.ajcem.20150303.12,
  author = {Torricelli Piera and Antonelli Francesco and Ferorelli Pasquale and De Martino Angelo and Shevchenko Anna and Beninati Simone},
  title = {Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {3},
  pages = {83-87},
  doi = {10.11648/j.ajcem.20150303.12},
  url = {https://doi.org/10.11648/j.ajcem.20150303.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150303.12},
  abstract = {In the pathogenesis of demyelinating diseases including multiple sclerosis (MS) an important role is played by oxidative stress. Increased energy requirements during remyelination of axons and mitochondria failure is one of the causes of axonal degeneration and disability in MS. In the presence of neurological diseases such as MS, F2-isoprostanes are concentrated in higher quantities. In this context, we analyzed the levels of F2-isoprostanes in the plasma and cerebrospinal fluid of mice of the strain C57BL6/N with an induced experimental autoimmune encephalomyelitis (EAE), orally treated with two concentrations of Citozym, a dietary supplement with evident antioxidant properties. Compared to the control group, Citozym-treated EAE-mouse had significantly lower levels of F2-isoprostanes both in plasma and in cerebrospinal fluid. Furthermore, according to the guidelines of IACUC, treatment with Citozym at higher concentrations drastically reduced neurological signs of induced EAE.},
 year = {2015}
}

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TY  - JOUR
T1  - Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis
AU  - Torricelli Piera
AU  - Antonelli Francesco
AU  - Ferorelli Pasquale
AU  - De Martino Angelo
AU  - Shevchenko Anna
AU  - Beninati Simone
Y1  - 2015/04/18
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150303.12
DO  - 10.11648/j.ajcem.20150303.12
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 83
EP  - 87
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150303.12
AB  - In the pathogenesis of demyelinating diseases including multiple sclerosis (MS) an important role is played by oxidative stress. Increased energy requirements during remyelination of axons and mitochondria failure is one of the causes of axonal degeneration and disability in MS. In the presence of neurological diseases such as MS, F2-isoprostanes are concentrated in higher quantities. In this context, we analyzed the levels of F2-isoprostanes in the plasma and cerebrospinal fluid of mice of the strain C57BL6/N with an induced experimental autoimmune encephalomyelitis (EAE), orally treated with two concentrations of Citozym, a dietary supplement with evident antioxidant properties. Compared to the control group, Citozym-treated EAE-mouse had significantly lower levels of F2-isoprostanes both in plasma and in cerebrospinal fluid. Furthermore, according to the guidelines of IACUC, treatment with Citozym at higher concentrations drastically reduced neurological signs of induced EAE.
VL  - 3
IS  - 3
ER  -

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Author Information

Torricelli Piera

Department SPES, University of Molise, Campobasso, Italy
Antonelli Francesco

University of Tor Vergata, Department of Biology, Rome, Italy
Ferorelli Pasquale

University of Tor Vergata, Department of Biology, Rome, Italy
De Martino Angelo

University of Tor Vergata, Department of Biology, Rome, Italy
Shevchenko Anna

People’s Friendship University of Russia, Department of medicine, Moscow, Russia
Beninati Simone

University of Tor Vergata, Department of Biology, Rome, Italy

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APA Style

Torricelli Piera, Antonelli Francesco, Ferorelli Pasquale, De Martino Angelo, Shevchenko Anna, et al. (2015). Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis. American Journal of Clinical and Experimental Medicine, 3(3), 83-87. https://doi.org/10.11648/j.ajcem.20150303.12

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ACS Style

Torricelli Piera; Antonelli Francesco; Ferorelli Pasquale; De Martino Angelo; Shevchenko Anna, et al. Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis. Am. J. Clin. Exp. Med. 2015, 3(3), 83-87. doi: 10.11648/j.ajcem.20150303.12

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AMA Style

Torricelli Piera, Antonelli Francesco, Ferorelli Pasquale, De Martino Angelo, Shevchenko Anna, et al. Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis. Am J Clin Exp Med. 2015;3(3):83-87. doi: 10.11648/j.ajcem.20150303.12

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@article{10.11648/j.ajcem.20150303.12,
  author = {Torricelli Piera and Antonelli Francesco and Ferorelli Pasquale and De Martino Angelo and Shevchenko Anna and Beninati Simone},
  title = {Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {3},
  pages = {83-87},
  doi = {10.11648/j.ajcem.20150303.12},
  url = {https://doi.org/10.11648/j.ajcem.20150303.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150303.12},
  abstract = {In the pathogenesis of demyelinating diseases including multiple sclerosis (MS) an important role is played by oxidative stress. Increased energy requirements during remyelination of axons and mitochondria failure is one of the causes of axonal degeneration and disability in MS. In the presence of neurological diseases such as MS, F2-isoprostanes are concentrated in higher quantities. In this context, we analyzed the levels of F2-isoprostanes in the plasma and cerebrospinal fluid of mice of the strain C57BL6/N with an induced experimental autoimmune encephalomyelitis (EAE), orally treated with two concentrations of Citozym, a dietary supplement with evident antioxidant properties. Compared to the control group, Citozym-treated EAE-mouse had significantly lower levels of F2-isoprostanes both in plasma and in cerebrospinal fluid. Furthermore, according to the guidelines of IACUC, treatment with Citozym at higher concentrations drastically reduced neurological signs of induced EAE.},
 year = {2015}
}

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TY  - JOUR
T1  - Multiple Sclerosis: Effect of Oral Administration of an Antioxidant Dietary Supplement in C57BL6/N Induced Model of Experimental Autoimmune Encephalomyelitis
AU  - Torricelli Piera
AU  - Antonelli Francesco
AU  - Ferorelli Pasquale
AU  - De Martino Angelo
AU  - Shevchenko Anna
AU  - Beninati Simone
Y1  - 2015/04/18
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150303.12
DO  - 10.11648/j.ajcem.20150303.12
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 83
EP  - 87
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150303.12
AB  - In the pathogenesis of demyelinating diseases including multiple sclerosis (MS) an important role is played by oxidative stress. Increased energy requirements during remyelination of axons and mitochondria failure is one of the causes of axonal degeneration and disability in MS. In the presence of neurological diseases such as MS, F2-isoprostanes are concentrated in higher quantities. In this context, we analyzed the levels of F2-isoprostanes in the plasma and cerebrospinal fluid of mice of the strain C57BL6/N with an induced experimental autoimmune encephalomyelitis (EAE), orally treated with two concentrations of Citozym, a dietary supplement with evident antioxidant properties. Compared to the control group, Citozym-treated EAE-mouse had significantly lower levels of F2-isoprostanes both in plasma and in cerebrospinal fluid. Furthermore, according to the guidelines of IACUC, treatment with Citozym at higher concentrations drastically reduced neurological signs of induced EAE.
VL  - 3
IS  - 3
ER  -

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